摘要
糖尿病对脑部结构功能有多方面影响，但糖尿病引发的认知功能障碍却常常被忽视。糖尿病性认知功能障碍的发生机制十分复杂，其中糖脂毒性、胰岛素抵抗、低血糖及Ca^2＋稳态被破坏等可能起重要作用。除糖尿病常规治疗方案外，糖尿病性认知功能障碍尚需要探索更加有效的治疗措施。
Diabetes can affect structure and function of brain in several aspects, but diabetic cognitive impairment is often ignored. The pathogenesis of diabetes associated cognitive impairment is complicated. Factors such as glucotoxicity, lipotoxicity, insulin resistance, hypoglycaemia and disturbance of Ca^2＋ homeostasis may play important roles. Besides conventional diabetes therapy, new methods still need to be explored.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2008年第5期476-479,共4页
Chinese Journal of Endocrinology and Metabolism
关键词
糖尿病
认知功能障碍
糖毒性
脂毒性
Diabetes mellitus
Cognitive impairment
Glucotoxicity
Lipotoxicity
