摘要
目的:制备氯化钾缓释片并考察其释药机制。方法:采用正交试验,以体外累积释药率为指标,优选包衣材料聚丙烯酰胺树脂及滑石粉的工艺参数。结果:以聚丙烯酰胺树脂4g/100g氯化钾、滑石粉用量7.5%为优化工艺所制氯化钾缓释片体外释放按零级模式释药。2、4、8h累积释药率分别大于26%、42%和94%,符合2005年版《中国药典》相关规定。结论:所制备缓释片工艺合理,体外释药效果良好。
OBJECTIVE： To preparation of potassium chloride sustained - release tablets and study its in - vitro release mechnism. METHODS： Technological parameters of tablets in coating materials includeded modified polyacrylamide resin and talc were decided by the accumulative releasing rate through the orthogonal test.RESULTS： It shows the optimized parameter as follows： polyacrylamide resin 4 g/100 g KCl, talc 7.5%. Releasing rate of KCI from tablets was demonstrated in accordance with zero profile. Accumulative releasing of 2, 4, 8 h are 〉 26%, 42%, 94% which according to Chinese Pharmacoeia （2005 Edition） .CONCLUSIONS： The sustained- release tablets thus prepared is proper in technique and well in vitro release effect.
出处
《中国药房》
CAS
CSCD
北大核心
2008年第31期2440-2442,共3页
China Pharmacy
关键词
氯化钾
缓释片
聚丙烯酰胺树脂
工艺
累积释药率
Potassium chloride
Sustained - release tablet
Polyacrylamide resin
Technology
Accumulative releasing rate
