摘要
目的:探讨妊娠期高血压疾病患者的不同程度蛋白尿对围生结局的影响。方法:选取妊娠期高血压疾病患者224例,分别进行24小时蛋白定量测定,按24h尿蛋白定量将患者分为轻度蛋白尿组(0.3～1.9g/24h)、中度蛋白尿组(2～4.9g/24h)和重度蛋白尿组(>5.0g/24h),同时测定入院时血压、血清尿素氮(BUN)、尿酸(UA)、肌酐(Cr)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、血小板(PLT)水平,并统计围生期结局。结果:224例中有轻度蛋白尿163例、中度蛋白尿42例、重度蛋白尿19例。严重并发症如胎盘早剥、低蛋白血症、产后出血和早产、死胎、低出生体重儿及胎儿宫内窘迫发生率随蛋白尿的排出增加而升高(P<0.05)。结论:妊娠期高血压患者的尿蛋白24小时定量测定与病情及围生儿的预后密切相关。随着尿蛋白的增加,母体出现严重并发症和胎儿围生期的风险增加,并是重度子痫前期发生或进展的信号。
Objective：To investigate the effect of the severity of proteinuria in patients with hypertensive disorder complicating pregnancy（HDCP） on their perinatal outcomes.Methods：224 patients with HDCP, different levels of proteinuria and integrity data of illness were selected. According to their 24-hour quantitative urine protein, the patients were divided into 3 groups： the moderate proteinuria group （0.3-1.9g/24h）, the severe proteinuria group （2-4.9 g/24h）, and the massive proteinuria group （〉5.0g/24h）. Among these groups, 24-hour quantitative urine protein was detected respectively. Blood pressure, blood urea nitrogen （BUN）, uric acid （UA）, crea- tinine, ALT, AST and the level of blood platelets （PLT） were simultaneously tested on admission, and the perinatal outcomes were recorded.Results：In 224 patients, 163 had moderate proteinuria, 0.3-1.9g/24h, 42 ones had severe proteinuria,2～4.9g/24h, and 19 had massive proteinuria, more than 5.0g/24h. The incidences of serious complications such as placental abruption, hypoproteinemia, postpartum hemorrhage increased along with the severity of proteinuria （P〈0.05）. And the incidences of neonatal premature birth, dead foetus, low birth weight infant and fetal distress in uterus increased along with the severity of proteinuria （P〈0.05）.Conclusion：Quantitative assay of 24-hour urine protein in patients with HDCP is closely related to patients＇ condition and perinatal outcomes. The risks of serious complications in women and perinatal foetus increase along with the severity of proteinuria.Massive proteinuria, which appears to be a marker for early onset and progression of severe pregnancy-induced hypertension（PIH）, can be used to monitor patients condition.
出处
《交通医学》
2008年第5期469-471,共3页
Medical Journal of Communications
关键词
妊娠期高血压疾病
蛋白尿
围生期结局
hypertensive disorder complicating pregnancy
Proteinuria
Perinatal outcomes
