摘要
目的观察小剂量纳洛酮对吗啡经小儿骶管镇痛效果及其不良反应的影响。方法60例3～6岁手术小儿随机均分为纳洛酮组(A组)和吗啡组(B组)。两组在骶管阻滞时给予1%利多卡因-吗啡混合液,A组术后24 h静脉持续泵注纳洛酮0.25μg·kg-1·h-1。分别于术毕1、4、8、16、24 h比较两组的镇痛效果,记录恶心呕吐、皮肤瘙痒和尿潴留等不良反应。结果两组镇痛效果差异无统计学意义;但A组恶心呕吐不良反应明显少于B组(P<0.05)。结论术后小剂量纳洛酮静脉持续泵注能减少小儿骶管吗啡镇痛时恶心呕吐的不良反应而不影响其镇痛效果。
Objective To observe the effects of small dose naloxone on the pain-relief and side effects of sacral morphine analgesia. Methods Sixty surgical children aged 3 to 6 years old were randomly divided into two goups with 30 cases each. The patients in group A and group B were caudally administered morphine combined with 1% lidocaine. Naloxone 0.25 μg · kg^-1 · h^-1 was continuously pumped after operation for 24 hours in group A. The analgesic efficacy was evaluated by VAS scoring and side effects such as pruritus, nausea, vomiting and urinary retention of two groups were recorded and compared at 1,4,8,16 and 24 hour after surgery. Results There was no significant difference of analgesia between two groups. The side-effects of nausea and vomiting in group A were significantly lower than those in group B （P〈0.05）. Conclusion Coneomitent intravenous pumping of small dose naloxone after operation can reduce the side-effects of nausea and vomiting during postoperative caudal analgesia with morphine without reducing its analgesic efficacy.
出处
《临床麻醉学杂志》
CAS
CSCD
2008年第10期851-852,共2页
Journal of Clinical Anesthesiology
关键词
纳洛酮
吗啡
骶管镇痛
小儿
Naloxone
Morphine
Caudal analgesia
Children
