摘要
淋巴管生成与肿瘤转移的相关性在肿瘤转移机制的研究中有着重要的意义,血管内皮生长因子C(VEGF-C)和VEGF-D是最具代表性的淋巴管生成因子,肿瘤组织可以生成大量的淋巴管生成因子,它们与相应的受体VEGFR-3结合诱导肿瘤性的淋巴管生成。实体瘤播散的最早途径是经淋巴道的区域性淋巴结播散,所以对肿瘤组织中淋巴管生成的研究有助于肿瘤转移的预防和开展新的治疗方法。
The relationship of tumor lymphangiogenesis and lymphatic metastasis had important significance in the research of tumor metastasis mechanism, VEGF-C and VEGF-D were representative lymphangiogenesis factors which tumor can produce massively, they can induce tumor lymphangiogenesis through being combined with their corresponding receptor VEGFR-3. The earliest way of solid tumor metastasis was through lymph vessels to regional lymph node, so the investigation of tumor lymphangiogenesis was helpful to prevent tumor metastasis and found the new way to cure cancer.
出处
《医学综述》
2008年第22期3419-3421,共3页
Medical Recapitulate
关键词
淋巴管生成因子
恶性肿瘤
淋巴道转移
Lymphangiogenesis factor
Malignant tumor
Lymohatic metastasis
