摘要
目的:制备姜黄素-聚维酮固体分散体,改善姜黄素的溶出度。方法:应用聚乙烯吡咯烷酮(PVPk30)为载体,以溶剂法制备固体分散体,差示扫描量热法、X-射线粉末衍射进行物相鉴定,并测定溶出度。结果:姜黄素在固体分散体中可能以无定型态或分子状态存在,药物的累积溶出百分率随载体比例增加而增加,以1∶6的比例效果最好。制成固体分散体后,药物在水中的溶解度达66.28g.L-1。结论:采用PVPk30制备的固体分散体能显著提高姜黄素的溶出度。
OBJECTIVE To prepare solid dispersion for increasing the dissolution of curcumin. METHODS Using polyvinyl pyrrolidone （PVPk30） as the carrier, solid dispersion was prepared by solvent evaporation method. The differential scanning calorimeter（DSC） and powder X-ray diffractometry （PXRD） were used to identify the state of the drug existence in the solid dispersion. The in vitro dissolution characteristics were studied in artificial gastric juice. RESULTS Curcumin existed as amor phous or molecular state in the solid dispersion. The in vitro dissolution rates of curcumin from all solid dispersions were larger than the pure drug and higher carrie-Curcumin ratio led to faster drug dissolution. The solubility of curcumin was improved by the solid dispersion and reached 66. 28 g·L^-1 in water. CONCLUSION The solid dispersion prepared with PVP could increase the dissolution of curcumin.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2008年第21期1819-1822,共4页
Chinese Journal of Hospital Pharmacy
基金
福建省重大专项前期研究项目(编号:2005YZ1010)
