摘要
本研究以人结肠癌SW－1116细胞体外培养后移植于Swiss－DF品系8周龄裸鼠双侧肾包膜下，次日以不同剂量天花粉蛋白（Trichosanthin，TCS）注射入裸鼠腹膜腔内。每天1次，连续5d，d8解剖裸鼠，观察天花粉蛋白对移植瘤体内抑制情况。结果显示：TCS剂量为0．75mg／kg组抑瘤率为41．2％（P＜0．01），优于丝裂霉素组（抑瘤率31．28％）0．5mg／kg组抑瘤率为27．5％（P＜0．05），远小于TCS对小鼠的半数致死量LD50（134mg／kg）。提示TCS体内应用安全度大，临床研究前景好。
Eight-week swiss-DF strain nude mice were transplanted in their bilateral subrenal capsules (SRC),with human SW-1116 colon carcinoma,then the different dosages of trichosanthin (TCS)were injected into nude mice speritoneal cavities next day after transplantation for 5 days,control groups were treated with normel saline (NS) (negative control ) and mitomycin-c (MMC ) (positive control ). The results showed that inhibition rate of TCS in 0. 75mg/kg group on the transplanted tumor was 41.20%,superior to that of MMC (31.28 % ). The effective dosage of TCS was 0.05mg/kg (P<0.05), much lower than LD50, (13. 4mg/kg) on mice. It suggested that TCS play a key role on inhibiting SW-1116 colon carcinoma in vivo and pro vide us a wide prospect as an antitumor drug.
出处
《海峡药学》
1997年第2期12-13,共2页
Strait Pharmaceutical Journal
关键词
天花粉蛋白
结肠癌
抗癌药
中医药疗法
Trichosanthin Colon neoplasm Antitumor drug Cancer-bearing nude mice
