摘要
目的探讨环氧化酶-2（COX-2）基因-765G/C多态性与冠心病易感性的关系。方法对226例经冠状动脉造影确诊的冠心病患者和240例正常人进行对照研究。应用聚合酶链反应限制性片断长度多态性技术测定COX-2基因-765G/C多态性。结果COX-2基因-765G/C多态性在冠心病组和正常人群（对照组）中分布的差异有显著性,冠心病组765G等位基因频率明显高于对照组（85.0%比79.4%,P〈0.05）。等位基因频率的相对风险分析发现,G等位基因携带者患冠心病的风险是C等位基因的1.471倍（95%CI：1.044-2.072）。结论COX-2基因启动子-765G/C多态性与冠心病发病具有相关性,其中G等位基因可能是冠心病发病的遗传易感基因。
Objective To investigate the association between cyclooxygenase-2 （COX-2） gene- 765G/C polymorphism and coronary heart disease （CHD） in Chinese population. Methods This was a case-control study,which enrolled 226 CHD patients diagnosed by angiography and 240 healthy controls. The genotype and allele frequencies of COX-2 gene polymorphism were assayed by polymerase chain reac- tion-restricted fragments length polymorphism （PCR-RFLP）. Results The distribution of COX-2 gene- 765G/C polymorphism was significantly different between CHD group and control group. The frequency of the COX-2 gene -765G allele in CHD patients was significantly higher than that of the control group（ 85. 0% vs 79.4% ,P 〈 0.05）. The relative risk for CHD in G allele carriers was 1. 471 times as high as that in C allele carriers （ OR = 1. 471,95% CI ： 1. 044 - 2. 072 ）. Conclusion COX-2 gene promoter region- 765G/C polymorphism is associated with CHD and G allele may be a risk factor for CHD.
出处
《临床内科杂志》
CAS
2008年第11期786-788,共3页
Journal of Clinical Internal Medicine
关键词
环氧化酶-2
冠心病
限制性片断长度多态性
Cyclooxygenase-2
Coronary heart disease
Restricted fragments length polymor- phism
