摘要
目的观察多囊肾病（PKD）患者泌尿生殖系统改变及其对男性生育力的影响。方法对3318例男性不育患者进行B超探查精囊腺、前列腺、睾丸、附睾、精索、肾脏和肝脏等，精液常规分析，232例正常生育成年男性作为对照组。多重PCR检测Y染色体无精子因子（azoospermia factor，AZF）微缺失。结果3318例男性不育患者中PKD5例（0．15％，5／3318）。发现PKD患者一家系7例。5例PKD患者（附睾囊肿5例，精囊囊肿3例），其中1例为无精子症，2例严重少精子症（精子密度〈5×10^6／ml），2例少精子、死精子症（精子密度〈20×10^6／ml而〉5×10^6／ml，100％死精子），检测到Y染色体AZF缺失1例。结论PKD合并生殖系统的囊性化阻塞可能是造成精子运输障碍引起男性不育的主要原因。
Objective To explore the influence of the adult polycystic kidney disease （PKD） on male reproductive function. Methods Ultrasonography was done to check the testis, epididymis, seminal vesicles, the kidneys and liver in 3318 infertile males. Two hundred and two adult healthy fertile men were served as control group. Ejaculates from 5 infertile males were examined by light microscopy to evaluate sperm concentration, motility and morphology. Y chromosome AZF microdeletions were detected by multiplex polymerase chain reaction （PCR） technique. Results Five cases of PKD were found in 3318 infertile males （0.15%, 5/3318） and one family of PKD with 7 cases was investigated. One of 5 infertile male cases with PDK was azoospermia, 2 of them were severe oligozoospermia （sperm density 〈5 × 10^6/ml） and 2 were oligozoospermia and necrospermia （sperm density from 〉5 × 10^6/ml to 〈20 × 10^6/ml, 100% of died spermatozoa）. The cystic epididymis were examined in all of 5 PKD infertile men and the cystic seminal vesicles was examined in 3 of them by ultrasound. The Y chromosome AZF microdeletion was found in 5 infertile men with PKD. Conclusion The cystic obstruction of reproductive system by PKD may be a possible cause of the sperm transport impediment in male infertility.
出处
《中国男科学杂志》
CAS
CSCD
2008年第10期44-47,共4页
Chinese Journal of Andrology
关键词
多囊肾疾病
不育
男性
polycystic kidney diseases
infertility, male
