摘要
对251例1型糖尿病(T1DM)患者进行胰岛细胞抗体(ICA)检测,发现ICA阳性组中谷氨酸脱羧酶抗体(GADA)和蛋白酪氨酸磷酸酶抗体(IA-2A)阳性率均显著高于ICA阴性组(P<0.01),空腹和餐后胰岛素水平明显低于ICA阴性组(P<0.05,P<0.01),胰岛素抵抗指数亦明显下降(P<0.05),提示T1DM患者中ICA阳性更易于合并有GADA、1A-2A阳性,且对胰岛β细胞功能的破坏更大。
251 patients with type 1 diabetes were collected to detect the level of islet ceil antibody（ICA）. The positive rates of GADA and IA-2A were higher in ICA positive group than in ICA negative group（P〈0.01）. While fasting and postprandial insulin levels were much lower in ICA positive group than in ICA negative group（P〈0. 05 or P〈0.01）. According to the increased insulin resistance index and reduced insulin sensitivity index in ICA negative group （P〈0.05）, islets with negative ICA may have less impairment and may secret more insulin.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2008年第11期674-675,共2页
Chinese Journal of Diabetes
关键词
胰岛细胞抗体
胰岛素抵抗
糖尿病
1型
Islet cell antibody
Insulin resistance
Diabetes mellitus, type 1
