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儿科院内感染肺炎克雷伯菌产超广谱β-内酰胺酶基因型检测及分析 被引量:3

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摘要 采用琼脂纸片扩散法和双纸片协同试验,对儿科院内感染肺炎克雷伯菌的耐药性及产超广谱β-内酰胺酶(ESBLs)菌株进行检测;用PCR检测耐药基因和DNA序列,分析产ESBLs菌株的基因型。结果从422份感染标本中分离出201株肺炎克雷伯菌,产ESBLs菌株阳性率39.4%(63/201);携带blaCTX-M-11基因17株(17/63,26.9%)、blaTEM-1基因7株(7/63,11.1%)、blaSHV-2基因5株(5/63,7.8%)。ESBLs阳性株对多种抗生素的耐药率高于ESBLs阴性株,只对亚胺培南敏感。提示吉林地区儿科院内感染肺炎克雷伯菌产ESBLs检出率高,并呈多重耐药性,携带三种ESBLs基因型。
出处 《山东医药》 CAS 北大核心 2008年第38期71-72,共2页 Shandong Medical Journal
基金 北华大学自然科学基金资助项目(2006-110)
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