摘要
目的了解新疆维吾尔自治区维、汉两民族中老年人群阿尔茨海默病（AD）和血管性痴呆（VD）的患病状况及分布特点，为深入研究AD的病因及防治提供基础资料。方法2004年7月到2007年6月，根据DSM-Ⅳ-R中痴呆的临床诊断标准和NINCDS—ADRDA标准，采用分层随机多级整群抽样方式，随机抽取新疆南疆、东疆、北疆、乌鲁木齐市市区，年龄大于50岁的维、汉族中老年人进行AD现患状况调查。结果共调查8284人，新疆维吾尔自治区维、汉两民族AD的粗患病率为3．66％（分别为3．24％和4．19％）。按2000年全国人口年龄构成标化，维、汉两民族总的AD标化患病率为3．50％（分别为2．68％和4．31％）；新疆维吾尔自治区维、汉两民族总的VD粗患病率为1．05％（分别为1．11％和0．97％）；维、汉两民族VD的标化患病率为0．98％（分别为1．00％和0．96％）。男女AD患病率在各年龄组间比较差异有统计学意义（维族χ^2=186．286，P=0．000；汉族χ^2=77．131，P=0．009），均随年龄增加而上升，AD患病率均随着文化程度的增高而明显降低。结论新疆维吾尔自治区维、汉两民族中老年人群AD的标化患病率明显高于全国平均水平，AD患病率高于VD；维、汉不同民族存在显著的族别、性别、年龄和文化间差异。
Objective To investigate Alzheimer＇ s disease（AD） and vascular dementia（VD） status and distribution in middle-aged and elderly population in Xinjiang Uigur and Han nationalities to provide the data for the further study of the causes and prevention of AD. Methods From July 2004 to June 2007, according to the DSM-IV-R diagnostic criteria for dementia and NINCDS-ADRDA criteria, multi-stage stratified random cluster sampling approaches were adopted in 6 areas in southern, eastern, northern Xinjiang Urumqi City Community to investigate middle-aged and elderly Uigur and Han people older than 50- year-old suffering from AD. Results A total of 8284 were surveyed, Xinjiang AD crude prevalence rate was 3. 66%, Uigur and Han AD accounting for 3.24% and 4. 19% respectively. According to the age composition of 2000 census of Xinjiang, AD adjusted standardized incidence was 3.50%, 2. 68% and 4. 31% for Uigur and Han respectively; Xinjiang VD crude prevalence rate was 1.05%, with Uigur and Han VD crude prevalence rates being 1.11% and 0. 97% ,respectively. Xinjiang VD standard rate was 0. 98%, Uigur and Han accounting for 1. 00% and 0.96% respectively. Prevalence rate of men and women had significant differences among age groups, and increased along with age （Uigurs χ^2 = 186. 286, P = 0. 000; Hans χ^2 = 77. 131,P = 0. 009）. The Uigur, Han AD prevalence rates obviously reduced with the increase of educationallevel（Uigurs χ^2 = 12.291,P=0.002;Hans χ^2 =61.539,P=0.000）. Conclusions AD standardized rate in the elderly in Xinjiang Uignr and Han ethnic groups is significantly higher than the national average. AD prevalence rate is comparably higher than that of VD. There are significant differences among the nationality, gender, age and culture.
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2008年第12期797-801,共5页
Chinese Journal of Neurology
基金
国家自然科学基金资助项目（30460140）
