摘要
对 2 0例男性慢性肺心病急性发作期患者和 2 0例正常人血浆内皮素 ( ET)进行测定。并同时测定肺心病患者的血氧分压 ( PO2 )和二氧化碳分压 ( PCO2 )。结果显示肺心病组血浆ET值明显低于对照组 ( P<0 .0 1 )。肺心病组 PO2 为 (1 0 .2 8± 1 .6 4) k Pa,PCO2 为(6 .5 7± 1 .6 8) k Pa。二者与血浆 ET无相关性。肺心病患者的血浆 ET降低可能是肺部毛细血管损伤和数目减少 ,血管内皮细胞受损和毁坏 ,产生 ET减少 ;以及肺对 ET的摄取和清除增多。与缺氧无直接关系。
The plasma endothelin and partial pressure of oxygen and carbon dioxide(PO-2 and PCO-2)were measured in 20 patients with acute attack of chronic cor pulmonale. The results showed that the level of plasma endothelin in patients with cor pulmonale was significantly less than that in the normal controls (P<0.01). The PO-2was (10.28±1.64)kPa, the PCO-2 was (6.57±1.68)kPa , they were not correlated with thd plasma endothelin in the patients with cor pulmonale. Decrease of the plasma endothelin was induced probably by injurying and decreasing of the endotheliocyte in the lungs , or by increasing intake and elimination of endothelin of the lungs. The decrease of the plasma endothelin in patients with the cor pulmonale was not directly related to the hypoxia.
出处
《皖南医学院学报》
CAS
1998年第2期118-119,共2页
Journal of Wannan Medical College
关键词
内皮素
血气分析
肺心病
缺氧
Endothelin
Blood gas analysis
Pulmonary heart disease
