摘要
目的:观察乙酰半胱氨酸及扎鲁斯特对急性肺损伤的防治作用。方法:大耳白兔32只,随机分为对照组、致伤组、乙酰半胱氨酸治疗组和扎鲁司特治疗组,每组8只。致伤组经颈静脉注入脂多糖(LPS,1 ml/kg);对照组注入生理盐水(1 ml/kg);乙酰半胱氨酸治疗组在注入LPS(1 ml/kg)前2 min,经颈静脉注入乙酰半胱氨酸(300 mg/kg);扎鲁斯特治疗组在注入LPS(1 ml/kg)前1 h及0.5 h,胃内注入扎鲁司特(20 mg/kg)。测定各组肺动脉压、动脉血氧分压、外周血白细胞计数、肺泡灌洗液(BALF)NO2-浓度、肺系数(肺湿重/体重)及肺湿/干比。结果:乙酰半胱氨酸组肺动脉压及NO2-浓度与致伤组有显著差别(P<0.05),乙酰半胱氨酸及扎鲁斯特组氧分压均较致伤组明显改善(P<0.05),肺系数和肺湿/干比显著均低于致伤组(P<0.05),外周血白细胞高于致伤组(P<0.05)。结论:乙酰半胱氨酸和扎鲁斯特对兔内毒素急性肺损伤有一定的保护作用。
Objective：To observe the preventive and cure effects of N -acetyl - L - cysteine and zafirlukast on acute lung injury. Methods：32 rabbits were randomly divided into 4 groups （n = 8） ： control group （CG） , injury group （IG） , N - acetyl - L - cysteine treated group （NG） and zafirlukast treated group （ZG）. Lipopolysaccharide （LPS,1 ml/kg） and saline （1 ml/kg） was injected into 1G and CG group, respectively. N - acetyl - L- eysteine （300 mg/kg） was given 2 rain before LPS （l ml/kg） injection in NG group while zafirlukast （20 mg/kg） was given 0.5 h and 1 h before LPS （1 ml/kg） injection, respectively. The pulmonary arterial pressure, PaO2, WBC, NO2^- concentration in the BALF, hung index （wet weight/body weight） and lung＇s wet/dry weight ratio （W/D） were detected in each group. Results：There were significant differences of the pulmonary arterial pressure and NO2^- concentration between NG and IG group （P 〈 0.05 ）. PaO2 in two treated groups was significantly improved compared with IG group （ P 〈 0.05 ）. Lung index and W/D ratio were significantly lower and WBC was higher in two treated groups than those in IG group （P 〈 0.05 ）. Conclusion： N - acetyl - L - cysteine and zafirlukast can prevent rabbits from acute lung injury induced by the endotoxin.
出处
《西南国防医药》
CAS
2009年第1期35-37,共3页
Medical Journal of National Defending Forces in Southwest China
关键词
急性肺损伤
乙酰半胱氨酸
扎鲁斯特
acute lung injury
N - acetyl - L - eysteine
zafirlukast
