摘要
目的探讨AQP1在非小细胞肺癌中的表达、意义及与HPA表达的相关性。方法应用免疫组织化学方法检测78例非小细胞肺癌组织标本和12例癌旁正常肺组织标本中AQP1和HPA的表达,分析AQP1的表达与患者临床病理特征、预后及HPA表达的相关性。结果腺癌、腺鳞癌和大细胞癌阳性表达率分别为57.5%,33.3%和20%,鳞癌无阳性表达。肺腺癌中AQP1的表达与N分期、复发/转移和生存时间密切相关(P<0.05),与HPA的表达呈正相关(P<0.05)。结论非小细胞肺癌中存在AQP1的表达,与HPA可能存在协同作用,促进肺腺癌的侵袭和转移。
Objective To investigate expression of AQPI in non-small cell lung cancer and its relationship with expression of HPA. Methods The expression of AQPI and HPA were tested by immunohistochenmical method in 78 surgically resected specimens of NSCLC. The relationships of its expression and clinical pathological feature, prognosis, expression of HPA were analyzed. Results The positive rates of AQPI in adenocareinoma, adenosquamous carcinoma, large cell carcinoma were 57.5%, 33.3%, 20% respectively. The expression of AQPI was correlated with lymph node stage, metastasis and survival time （ P 〈 0. 05 ） in adenocarcionma. The expression of AQPI had positive correlation with HPA in lung adenocarcinoma （P 〈 0. 05）. Conclusion There is expression of AQPI in NSCLS. The interaction of AQPI and HPA may co-regulate the progress of lung adenocarcinoma.
出处
《临床肺科杂志》
2009年第2期207-209,共3页
Journal of Clinical Pulmonary Medicine
