摘要
目的观察低浓度一氧化氮（ＮＯ）吸入对高原肺水肿的治疗作用。方法６５例男性高原肺水肿患者，随机分为３组。常规治疗组（１９例）接受吸氧、静脉注射速尿、氨茶碱和地塞米松治疗；硝苯吡啶组（２４例）在常规治疗的基础上加服硝苯吡啶１０ｍｇ，３次／日；ＮＯ组（２２例）在硝苯吡啶治疗的基础上，一次性吸入１０ｐｐｍＮＯ３０分钟。比较各组病例肺部音、Ｘ线胸片阴影消失时间以及病程长短。结果ＮＯ组肺部音消失时间为０４±０３天，Ｘ线胸片阴影消失时间为０６±０２天，病程１８±０７天，与硝苯吡啶组（分别为２４±１４天，４１±１７天，６８±１８天）和常规治疗组（分别为３７±１２天，５５±１８天，９６±３１天）比较差异均有显著性。结论在常规治疗与硝苯吡啶治疗的基础上，吸入低浓度ＮＯ是治疗高原肺水肿比较有效的方法。
Objective To investigte the therapeutic effect of low concentration of nitroic oxide (NO) inhalation in high altitude pulmonary edema. Method Sixty five male patients with high altitude pulmonary edema were randomized into three groups. Patients in the conventional therapy group received oxygen, intravenous furosemide, aminophylline and dexamethasone; patients in the nifedipine group received oral nifedipine (10 mg, tid) in addition to conventional therapy; and patients in the NO group received NO (10 ppm) inhalation for 30 min, in addition to oral nifedipine. The time for which pulmonary rales on auscultation and shadows on chest radiograph lasted, and the course of disease, were compared. Result In the NO group, pulmonary rales disappeared in 0.4±0.3 d, shadows on chest radiograph disappeared in 0.6±0.2 d, and the course of disease was 1.8± 0.7 d, all of which were significantly different from those of the nifedipine group (2.4±1.4 d, 4.1±1.7 d, 6.8± 1.8 d, respectively) and the conventional therapy group (3.7±1.2 d, 5.5± 1.8 d, 9.6±3.1 d, respectively). Conclusion Low concentration NO inhalation on the basis of conventional and nifedipine therapies was very effective in the treatment of high altitude pulmonary edema, which deserves further and larger scale investigation.
出处
《中华结核和呼吸杂志》
CAS
CSCD
北大核心
1998年第4期212-214,共3页
Chinese Journal of Tuberculosis and Respiratory Diseases
基金
全军医药卫生科研基金
关键词
肺水肿
一氧化氮
高原病
治疗
Pulmonary edema Nitric oxide Altitude siokness
