摘要
目的:观察宫颈上皮内瘤变(CIN)患者LEEP刀术后加用重组人干扰素-α2b阴道泡腾胶囊治疗的疗效。方法:136例病例随机分为两组,对照组75例,治疗组61例。两组患者在月经干净后3-7 d内行LEEP手术,治疗组患者在LEEP术后于宫颈管创面放置重组人干扰素-α2b阴道泡腾胶囊。对照组未放置任何药物。观察两组患者宫颈创面愈合时间、术后并发症的发生情况及HPV持续感染率。结果:两组患者宫颈创面愈合时间、并发症发生情况比较有显著性差异(P<0.01,P<0.05);HPV持续存在率有显著性差异(P<0.01)。结论:LEEP术后使用重组人干扰素-α2b阴道泡腾胶囊,HPV持续存在率显著降低,宫颈创面愈合时间缩短,术后创面肉芽增生等并发症明显减少,临床效果好,值得推广。
To observe the effect of the recombinant vescent capsule combined with LEEP in cervical intraepit human interferon alpha-2b vaginal efferhelial neoplasia. Methods： A total of 136 patients were randomly divided into two groups： control group（n=75） and treatment group（n= 61）. I.EEP was done during 3-7 d after menstrual clean in both groups. Recombinant human interferon alpha 2b vaginal effervescent capsule was placed into the wound of cervical canal after LEEP in the treatment group. The healing time, post-operative complications and persistent infection rate of HPV were observed in the two groups. Results： There were significant differences in the efficacy, complications and persistent infection rate of HPV in two groups （P〈0.01, P〈 0.05 and P〈0.01 respectively）. Conclusion： The use of recombinant human interferon alpha-2b vaginal effervescent capsule after LEEP contributes to decreasing the persistent infection rate of HPV, shortening the wound bleeding time and reducing the post-operative complications such as wound granulation hyperplasia.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2009年第1期127-129,共3页
Medical Journal of Wuhan University
