摘要
目的观察α-硫辛酸、川芎嗪联合治疗糖尿病周围神经病变的疗效。方法50例糖尿病周围神经病变的患者，随机分为2组，对照组给予川芎嗪100mg加入生理盐水中静脉滴注，1次／d，共3周；治疗组27例，在此基础上给予给予α-硫辛酸600mg加生理盐水静脉滴注，1次／d，共3周；观察治疗前后临床症状和体征变化，神经传导速度。结果治疗组总有效率达85．19％，对照组总有效率43．48％，两组比较差异有显著意义（Х^2=9．62，P〈0．05）；治疗后治疗组神经传导速度的改善较对照组明显，有显著性差异（t=2．341、2．718，P〈0．05）。结论α-硫辛酸、川芎嗪可明显改善糖尿病周围神经病变。
Objective To investigate the curative effect of a-lipoic acid binding with Ligustrazine in treating dial）etie peripheral neuropathy. Methods 50 patients of diabetic peripheral neuropathy were divided randomly into 2 groups. The control group was provided 100mg Ligustrazine with saline dropping for 3 weeks. The 27 samples of cured group were treated with 600rag a-lipoic acid with normal saline liquid vein drop- ping,qd, for 3 weeks. The clinic symptom,body symptom variation and nerve conduction velocity （NCV） before and after the treatment were calculated. Results The effective rate of cured group was higher than control group （85. 19% vs 43.48%, P 〈 0.05 ）. After treatment, the improvement of NCV for the cured group was better than the compared group （ t = 2. 3411,2.718, P 〈 0.05 ）, Conclusion α-lipoic acid combined with Ligustrazine can obviously treat diabetic peripheral neuropathy.
出处
《医学综述》
2009年第2期316-317,共2页
Medical Recapitulate
