摘要
目的合成含有氨基和羧基的水溶性β－环糊精衍生物并测试其性能，这些化合物用作毛细管电泳添加剂．方法将β－环糊精与含有氨基的化合物在碱性条件下用环氧氯丙烷连接起来．结果合成了七（２，６－二－Ｏ－羧甲基）－β－环糊精（羧甲基－β－ＣＤ）、七｛２，６－二－Ｏ－［３－（２－氨基乙氨基）－２－羟丙基］｝－β－环糊精（乙二胺－β－ＣＤ）、七｛２，６－二－Ｏ－［３－（１，３－二羧基丙氨基）－２－羟丙基］｝－β－环糊精（谷氨酸－β－ＣＤ）、七｛２，６－二－Ｏ－［３－羧甲基氨基）－２－羟丙基〗｝－β－环糊精（甘氨酸－β－ＣＤ）、七｛２，６－二－Ｏ－［３－（１，２－二羧基乙氨基）－２－羟丙基］｝－β－环糊精（天冬氨酸－β－ＣＤ）、七｛２，６－二－Ｏ－［３－氨基－２－羟丙基）ｑ－β－环糊精（氨基－β－ＣＤ）、七｛２，６－二－Ｏ－［３－（２－羟基乙氨基）－２－羟丙基］｝－β－环糊精（乙醇氨－β－ＣＤ）等七种含有氨基和羧基的β－环糊精衍生物，结果表明它们具有良好的水溶性．将羧甲基－β－ＣＤ和谷氨酸－β－ＣＤ用作毛细管电泳添加剂分离了异丙嗪和扑尔敏两种手性异构体，得到了较好的分离结果．结论将氨基和羧基引入环糊精后可极大改善β－环糊精的水?
Aim\ To synthesize water soluble β-cyclodextrin derivatives containing amino groups and carboxyl groups and test their characteristics These derivatives were used as selective teagents ofr electrophoresis Methods\ β cyclodextrin reacted with amino group and carboxyl group containing compounds in the presence of KOH and epichlorohydrin in water, and the water soluble β cyclodextrin derivatives were produced Results\ Seven β cyclodextrin derivatives were synthesized, which possessed the high water soluble property Some of them showed excellent results when they were used as selective reagents to separate chiral isomers Conclusion\ β cyclodextrin derivatives containing amino groups and carboxyl groups have excellent water solubility, and can be used as selective reagents for the separation of chiral isomers
出处
《北京理工大学学报》
EI
CAS
CSCD
1998年第2期159-164,共6页
Transactions of Beijing Institute of Technology
基金
国家自然科学基金
