摘要
目的了解鲍氏不动杆菌的临床分离情况及对常用抗菌药物的耐药性变迁趋势,为指导临床合理用药提供理论依据。方法回顾性分析2001-2006年中国医科大学附属第一医院临床分离的668株鲍氏不动杆菌的药敏结果,采用K-B琼脂扩散法,结果判定参照2006年NCCLS/CLSI标准。结果医院鲍氏不动杆菌的分离数由2001年的61株上升到2006年247株,耐药水平也在不断增高,其中环丙沙星、庆大霉素及亚胺培南的耐药率分别由2001年的29.5%、24.6%及4.9%上升到2006年的64.8%、72.9%及48.6%;随机筛选的50株多药耐药鲍氏不动杆菌对多黏菌素B的耐药率为18.6%。结论6年来医院鲍氏不动杆菌检出率呈稳步上升,鲍氏不动杆菌耐药率较高,故应加强对其的耐药监测并明确耐药机制。
OBJECTIVE To study the changing trends of drug-resistance of Acinetobacter baumannii isolates. METHODS All 668 isolates of A. baumannii were obtained from clinical patients in the First Affiliated Hospital of China University of Sciences Medical between 2001-2006. K-B test was used to determine the susceptibility and the results were read based on National Committee for Clinical Laboratory Standards （NCCLS）of the USA. RESULTS The number of A. baurnannii isolates was increasing from 61 in the year of 2001 to 247 in the year of 2006. And during the six years, the resistant rate to ciprofloxacin, gentamicin and imipenem was increasing from 28.8%, 25. 4%, 5. 4% to 64.9%, 72. 7% and 48. 5%, respectively. The resistant rate of the 50 multidrugresistant A. baurnannii isolates to polymyxin B was 18. 6%. CONCLUSIONS During the six years, the isolating rate is increasing,the result showed that there is not a large scale outbreak. The resistant rate is so high that we must strengthen the monitoring and indentify the drug-resistance mechanisms.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2009年第2期217-219,共3页
Chinese Journal of Nosocomiology
关键词
鲍氏不动杆菌
耐药性
分析
Acinetobacter baumannil
Drug-resistance
Analysis
