摘要
目的探讨胃神经内分泌肿瘤和胃癌伴神经内分泌分化的临床病理特征。方法回顾性分析10例胃神经内分泌肿瘤和4例胃癌伴神经内分泌分化患者的临床病理资料,并对其组织化学及免疫组织化学SP法染色进行观察。结果胃神经内分泌肿瘤和胃癌伴神经内分泌分化均好发于老年人,患者临床症状相似,以晚期多见,肿块大多为溃疡型,好发于胃贲门部或胃窦部。10例胃神经内分泌肿瘤中,典型类癌2例,不典型类癌3例,小细胞癌5例,癌细胞均表达神经内分泌标记物,嗜铬素A(CgA)、突触素(Syn)及神经元特异性烯醇化酶(NSE)阳性。4例胃癌伴神经内分泌分化见少数神经内分泌标记物阳性的肿瘤细胞散在分布于胃癌组织内,其癌成分为管状腺癌,表达癌胚抗原(CEA)、上皮膜抗原(EMA),黏液染色(AB/PAS)阳性。结论胃神经内分泌肿瘤以不典型类癌及小细胞癌为主,大多恶性度高,胃癌伴神经内分泌分化不影响胃癌的恶性度,两者属于不同的组织学类型,分型对其治疗有指导意义。
Objective To investigate the elinieo - pathological characteristics of gastric neuroendocrine tumor （NET） and gastric carcinoma with neuroendoerine cell differentiation. Methods We reviewed the clinical and pathological data of 10 patients with gastric NET and 4 with gastric carcinoma with neuroendocrine cell differentiation. Histochemical and immunohistochemical stain were performed. Results The symptoms of the patients were similar, presenting mainly at advanced stage. Most tumors were ulcer type, their favourite sites were in the cardia or antrum. Two of 10 NET patients were diagnosed as typical tumour, 3 as atypical, 5 as small cell carcinoma. Every cancer cell showed a neuroendoerine marker, such as chromogranin A （CgA）, positive synaptophysin （Syn） and neuronspecific enolase （NSE）. In 4 patients with gastric carcinoma with neuroendocrine cell differentiation. , a small number of positive tumor cells of neuroendocrine tumor markers were noted to scatter in gastric cancer tissues, and their components were tubular adenocareinoma, expression of carcinoembryonic antigen （CEA） , epithelial membrane antigen （EMA） and positive mucus staining （AB/PAS）. Conclusion Gastric neuroendocrine tumors are mainly atypical and small cell carcinoma, most with high malignancy; gastric cancer with neuroendoerine differentiation does not affect the gastric cancer malignancy. They are in different histological types, and typing is of instructive significance in their treatment.
出处
《中国全科医学》
CAS
CSCD
北大核心
2009年第4期320-322,共3页
Chinese General Practice
关键词
胃
神经内分泌肿瘤
癌
神经内分泌
Stomach
Neuroendoerine tumors
Careinoma, neuroendocrine
