摘要
目的探讨肺癌患者不同临床分期、组织学类型血清内皮抑素水平,从而判断血清内皮抑素水平对肺癌的早期诊断的价值。方法对81例肺癌患者、23例良性肺病患者和20例健康者用ELISA方法检测血清内皮抑素。对不同临床分期、病理类型血清内皮抑素的水平进行分析。结果1)肺癌组血清内皮抑素水平(12.53±8.75)ng/mL高于良性肺病组(4.63±1.12)ng/mL和健康对照组(4.53±1.24)ng/mL,差异有统计学意义;2)Ⅰ、Ⅱ期肺癌患者血清内皮抑素的水平高于Ⅲ期,差异有统计学意义;3)肺癌患者不同病理类型血清内皮抑素水平的比较差异有统计学意义。结论血清内皮抑素有可能成为肺癌早期诊断的参考指标。
Objective To measure the serum levels of endostatin in lung cancer patients in dif ferent stages and with histological types, and explore the clinical value of serum level in early diagnosis of lung cancer. Methods ELISA was used to detect the level of serum endostatin in 81 patients with lung cancer （lung cancer group）, 23 patients with benign lung disease （benign lung disease group）, 20 healthy controls （healthy control group）. The serum levels of endostatin were analyzed in lung cancer patients in different stages and with histological types. Results The serum level of endostatin in lung cancer group was （2.53±8.75） ng/mL, significantly higher than that in benign lung disease group （4.63±1.12） ng/mL and healthy control group （4.53±1.24） ng/mL. In lung cancer group, the ser- um level of endostatin of stage I subgroup and H subgroup was significantly higher than that of stage []I subgroup. The differences were statistically significant. There were statistical differences of serum level of endostatin among the lung cancer patients with different histological types. Conclusion Serum endostatin might be used as an indicator of early diagnosis of lung cancer.
出处
《国际检验医学杂志》
CAS
2009年第1期39-40,共2页
International Journal of Laboratory Medicine
关键词
肺肿瘤
内皮抑素类
血清学试验
诊断
Lung neoplasms
Endostatins
Serologic tests
Diagnosis
