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神经酰胺的代谢及其在细胞凋亡中的作用 被引量:2

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摘要 神经酰胺是鞘脂类,作为第二信使普遍存在于细胞膜和细胞质之间并传递信号,是进化上保守的信号系统。现在已有的研究数据表明,电离辐射、紫外线、氧化应激等细胞外应激因子均能迅速激活细胞膜上的酸性鞘磷脂酶,水解鞘磷脂产生神经酰胺,从而诱导细胞凋亡,而且神经酰胺代谢中的很多产物,如鞘氨醇-1-磷酸具有抗凋亡活性,能控制凋亡反应强度,有助于阐明细胞抗辐射的机制。
出处 《科技信息》 2008年第33期22-22,58,共2页 Science & Technology Information
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