摘要
目的:探讨不同性别及年龄段乙肝患者HBV-DNA含量的变化规律。方法:选择经ELISA检测为HBsAg阳性携带者血清465例,采用荧光定量聚合酶链反应(FQ-PCR)技术测定血清HBV-DNA含量,并根据不同性别及年龄段HBV-DNA含量进行相关性分析。结果:465例HBsAg阳性标本中,所检测的乙肝患者HBV-DNA含量随年龄增长逐渐下降。30岁以前男性患者HBV-DNA含量比女性患者高,而31岁以后女性患者HBV-DNA含量较男性患者较高;HBV-DNA平均含量男性患者大于女性患者。结论:HBV-DNA含量与年龄呈负相关;HBV-DNA含量男性明显高于女性;乙肝患者应做HBV-DNA检测,有助于HBV感染者传染性大小的判断以及对抗病毒药物临床疗效的评价,以确定最佳治疗方案。
Objective： To discuss the change law of HBV-DNA content in hepatitis B patients with different sex and age. Methods： The serum HBV-DNA content of 465 cases of HBsAg positive carriers confirmed by ELISA method was determined by fluorescence quota polymerase chain reaction （FQ-PCR）, and the correlation analysis was performed according to the HBV-DNA content of different sex and ages. Results： In 465 cases of HbsAg positive specimen, the HBV-DNA content of hepatitis B patients decreased gradually along with the growth of age; the HBV-DNA content in males was higher than that in females before 30 years old, but the HBV-DNA content in females was higher than that in males after 31 years old. Male patients showed a higher average HBV-DNA content than that in female patient. Conclusion： HBV-DNA content shows a negative correlation with age, and males show a higher HBV-DNA content than that in females. HBV-DNA detection is contribute to the judgment of infectiousness of HBV infected individuals and the evaluation of clinical effect of anti-virus drugs and further to decide the best therapeutic scheme.
出处
《中国医药导报》
CAS
2009年第5期121-122,共2页
China Medical Herald
