摘要
目的探讨经颅磁刺激方法对帕金森病患者睡眠结构及睡眠质量的影响。方法对2006年9月至2007年12月河北医科大学第一医院神经内科收治的15例已确诊,Hoehn-Yahr分期在1～2期的帕金森病患者进行经颅磁刺激治疗,治疗前后分别进行国际统一帕金森病量表评测及多导睡眠脑电监测。结果15例帕金森病患者的临床评分(UPDRS)由治疗前的38.83±16.72下降到25.09±11.10,差异有统计学意义(P<0.05),多导睡眠监测显示,患者的总睡眠时间由治疗前的(318.35±92.49)min增加到(333.9±59.04)min,虽然有增加趋势,但差异无统计学意义。入睡潜伏期由治疗前的(53.50±46.40)min减少到(30.43±23.91)min,较治疗前明显缩短,差异有统计学意义(P<0.05)。治疗后患者进入Ⅰ期睡眠后维持时间减少,但差异无统计学意义;进入Ⅱ期睡眠维持时间较治疗前无明显变化,个别患者能够进入Ⅲ期、Ⅳ期睡眠,可持续数分钟。睡眠效率、中间觉醒时间、快速动眼(REM)期睡眠和REM期潜伏期治疗前后差异均无统计学意义。结论在刺激频率为0.5Hz,最大刺激强度为2.0T,给予阈上30%的刺激强度下的经颅磁刺激能缩短帕金森病患者睡眠潜伏期,并可能会增加深睡期时间,但对帕金森病的睡眠结构无明确的调整作用。
Objective To study the possible effects of transcranial magnetic stimulation （TMS） on the sleep structure of the patients with Parkinson＇s disease. Methods Fifteen PD patients attending an outpatient Movement Disorders Unit at Department of Neurology, Cerrahpasa Faculty of Medicine, between September 2006 and December 2007 were included in the study. All patients had received TMS treatment. The stimuli were delivered through a circular coil with a 12 cm diameter and a 2. 0 T peak magnetic field. They underwent clinical evaluation and polys omnograpbic （PSG） evaluation before and after a minimum treatment period of 10 days with TMS. Results The mean UPDRS score was significantly decreased after TMS（ before treatment,38.83± 16. 72 ;after treatment,25. 09 ± 11.10）. PSG revealed that administration of TMS resulted in significant decrease in mean Sleep latency [ before treatment, （ 53.50 ± 46.40 ） min ; after treatment, （ 30. 43± 23.91 ）mini. Slow wave （stage 3 ＋4） was found in somes patients after treatment. But here was a trend towards an decrease in Percentage of stage 1 ,REM latency and REM sleep without significance. Conclusion This study demonstrates that motor symptom of PD was improved and Sleep latency was decreased by TMS. Sleep structure was not changed before and after TMS treatment.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2009年第2期132-134,共3页
Chinese Journal of Practical Internal Medicine
基金
河北省卫生厅资助课题(04162)
关键词
帕金森病
经颅磁刺激
睡眠结构
Parkinson＇s disease
transcranial magnetic stimulation
sleep structure
