摘要
目的通过测定不同2型糖尿病患者血糖、血压、体重指数、血胰岛素水平,检测视网膜病变、颈动脉内-中膜厚度及ACEI类用药史患者的尿微量白蛋白与肌酐的比值,了解上述因素对尿微量白蛋白与肌酐比值的影响。方法选取内蒙古林业总医院内分泌科2006年9月～2007年1月住院的2型糖尿病患者352例,其中尿微量白蛋白与肌酐比值异常组男性65例≥25mg/g,女性41例≥35mg/g;尿微量白蛋白与肌酐比值正常组男性132例﹤25mg/g,女性114例﹤35mg/g。按其年龄、性别、病程分别测定血糖、血压、体重指数、血胰岛素水平,检测视网膜病变、颈动脉内-中膜厚度及ACEI类用药史患者尿微量白蛋白与肌酐比值并作分析。结果(1)尿微量白蛋白与肌酐比值升高的2型糖尿病患者与比值正常者比较,表现为更高的血糖、体重指数、血压(P<0.05)。(2)合并视网膜病变、颈动脉内-中膜厚度增厚的患者尿微量白蛋白与肌酐比值升高明显(P<0.05)。(3)ACEI类用药史的患者尿微量白蛋白与肌酐比值的数值低于未用ACEI者(P<0.05)。(4)性别、年龄、胰岛素水平与尿微量白蛋白与肌酐比值无统计学意义(P>0.05)。结论良好的血糖、体重指数、血压的控制及应用ACEI类药物可有效地降低2型糖尿病患者尿微量白蛋白与肌酐的比值,延缓糖尿病肾病的发生发展。
Objective To determine blood glucose, the blood pressure body mass index（BMI）, blood insulin level, fundus disease, arterial carotis interior-tunica media thickness, and angiotensin-converting enzyme inhibitor[ACEI] medicine taken of the distinct 2 type diabetes,and analyse the effects on ratio of urinary albumin to creatinine （A/C） about above-mentioned factors. Methods Totally 352 hospital patients with 2 type diabetes in endocrine secretion department of Inner Mongolia forestry general hospital from 2006,9 to 2007, 1 the 106 patients of A/C abnormal group,among male 65 cases ≥25mg/g,female 41 cases ≥35mg/g; the 246 patients of A/C normal group,among male 132 cases 〈 25rag/g, femal 114 cases 〈 35mg/g; According to age, sex, course of disease, blood glucose, blood pressure, body mass index （BMI）, blood insulin level,fundus disease, arterial carotis interior-tunica media thicknes and angiotensin-converting enzyme inhibitor[ACEI] medicine taken of the distinct 2 type diabetes, respectively to determine the ratio of urinary albumin to creatinine and analyses them. Results （ 1 ）To compare the A/C abnormal group with the A/C normal group,the A/C abnormal group,appear hyperglycemia,hypertension,body mass index（BMI） （P〈 0.05 ）, to have statistical significance. （2）Complicating fundus pathological changes, neuropathy and arteria carotis interior-tunica media thickening patients,the urinary ratio of albumin to creatinine obviously rise（P〈 0.05 ）, to have statistical significance. （3）To take angiotensin-converting enzyme inhibitor（ACEI） medicine patients,the urinary ratio of micro albumin to creatinine obviously decline（P〈 0.05）, to have statistical significance. （4）Age, sex and the insulin level with the urinarty ratio albumin to creatinine had not statistically significant（P〉0.05）. Conclusion To satisfactorily control the blood glucose, blood pressure, body mass index（BMI） and take ACEI medicine could utilitily control the urinary ratio of albumin to creatinine rise. And postpone the renal disease happen and development,to promptly find the big and small vessels and neuropathy,it could hint the renal lesions development.
出处
《中国现代医生》
2009年第4期10-11,26,共3页
China Modern Doctor
