摘要
目的:观察α硫辛酸与甲钴胺联合应用治疗糖尿病周围神经病变的疗效。方法:选择80例糖尿病周围神经病变患者,随机分成联合用药组(治疗组)和单药组(对照组),每组各40例。治疗组给予α硫辛酸和甲钴胺联合治疗,对照组单用甲钴胺治疗,疗程均为4周。观察两组治疗后的临床疗效及神经传导速度(NCV)。结果:治疗组总有效率达92.5%,明显高于对照组的62.5%(P<0.05);治疗后治疗组神经传导速度较对照组有显著提高(P<0.05)。结论:α硫辛酸与甲钴胺联合治疗糖尿病周围神经病变较单用甲钴胺治疗,更能有效改善糖尿病周围神经病变患者的症状和神经传导速度。
Objective：To observe the therapeutic effect of α lipoic acid combined with mecobalamin on diabetic peripheral neuropathy（DPN）. Methods： 80 patients with diabetic peripheral neuropathy were randomly divided into the combination treatment group （treatment group,40 cases） and single-drug group （control group,40 cases）. The treatment group were treated by α lipoic acid and mecobalamin,the control group were treated by mecobalamin. The treatment courses were 4 weeks for both groups. They were observed the therapeutic effect and nerve conduction velocity （NCV） [or the two groups at the end of treatment. Results： The total efficacious rate of treatment group reaches 92.5%,was higher than the control group 62. 5 % （P〈0. 05） ;After the treatment for 4 weeks,the treatment group＇s nerve conduction velocity was significantly improved（P〈 0.05） than the control group. Conclusions： α lipoic acid combined with mecobalamin is effective in treating diabetic peripheral neuropathy,can effectively improve nerve conduction velocity of the DPN patients.
出处
《中国冶金工业医学杂志》
2009年第1期14-15,共2页
Chinese Medical Journal of Metallurgical industry
关键词
Α硫辛酸
甲钴胺
糖尿病
周围神经病变
α lipoic acid
Mecobalamin
Diabetes,Peripheral neuropathy
