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甘精胰岛素联合瑞格列奈对磺脲类继发失效老年糖尿病人的疗效和胰岛功能的影响 被引量：17

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摘要 目的探讨磺脲类药物继发性失效的老年糖尿病患者加用甘精胰岛素(GL)或中性鱼精蛋白锌胰岛素(NPH)的疗效和治疗前后胰岛功能的变化。方法对磺脲类药物继发性失效的54例老年糖尿病患者,改用瑞格列奈,并分别于睡前注射GL(26例)或NPH(28例),观察16w前后空腹血糖、餐后2h血糖、糖化血红蛋白、空腹C肽、餐后C肽的变化。结果两组均有显著的降血糖作用,且所用的胰岛素剂量相近,但GL组的低血糖事件明显少于NPH组,且GL组治疗后C肽水平明显升高。结论睡前注射NPH或GL均对磺脲类药物继发性失效的老年糖尿病患者有很好的疗效,但应用GL低血糖发生率低,且可能改善胰岛功能。
作者 赵江波 袁国跃 吴晖
机构地区 江苏大学附属医院内分泌科 浙江大学医学院附属邵逸夫医院内分泌科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2009年第4期469-471,共3页 Chinese Journal of Gerontology
关键词 老年糖尿病 甘精胰岛素 瑞格列奈 胰岛功能
分类号 R589.1 [医药卫生—内分泌]
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参考文献8

  • 1程桦,傅祖植,李焱,陈劲松,陆祖谦,黄仕泽,钟光恕,陈玉驹,严棠.四项基本临床试验在非胰岛素依赖型糖尿病优降糖继发失效时的应用[J].中国糖尿病杂志,1994,2(3):130-133. 被引量：24
  • 2Janka HU, Plewe G, Riddle MC,et al. Comparison of basal insulin added to oralagents versus twice-daily premixed insulin as initial insulin therapy for type 2 diabetes[J]. Diabetes Care,2005; 28 (2) :254-9.
  • 3Jovarovic L, Daily G, Huang WC,et al. Repaglinide in type 2 diabetes: a 24-week ,fixed-dose efficaly and safety study[ J ]. Pharmacology, 2000 ;40 ( 1 ) :49-57.
  • 4Rosenstock J, Dailey G, Massi-Benedetti M, et al. Reduced hypoglycemia risk with insulin glargine:a meta-analysis comparing insulin glargine with human NPH insulin in type 2 diabetes[ J]. Diabetes Care,2005 ;28:950- 95.
  • 5Riddle MC, RosenstockJ, Gerich J, et al. The treat-to-target trail : randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients[ J]. Diabetes Care,2003 ;26:3080-6.
  • 6Dunn CJ,Plosker GL, Keating GM, et al. Insulin glargine:an updated review of its use in the management of diabetes mellitus [ J ]. Drugs,2003; 63 : 1743-78.
  • 7Kurtzhals P, Schaffer L, Sorensen A, et al. Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use [ J ]. Diabetes,2000 ;49:999-1005.
  • 8傅静奕,李焱,严励,张淼,陈黎红,傅祖植.甘精胰岛素对游离脂肪酸诱导的RIN-m细胞凋亡的影响[J].中山大学学报（医学科学版）,2005,26(4):413-416. 被引量：28

二级参考文献12

  • 1Kurtzhals P, Schaffer L, Sorensen A, et al. Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use[J]. Diabetes, 2000, 49(6):999-1005.
  • 2Rakatzi I, Seipke G, Eckel J. [LysB3,GluB29 ]insulin:a novel insulin analog with enhanced b cell protective action [J]. Biochem Biophys Res Commun, 2003, 310(3):852-59.
  • 3Zhou YP, Grill VE. Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle[J]. J Clin Invest, 1994, 93(2):870-76.
  • 4Gerich JE. Contributions of insulin-resistance and insulin-secretory defects to the pathogenesis of type 2diabetes mellitus [J]. Mayo Clin Proc, 2003, 78(4):447-56.
  • 5Kahn SE. The importance of the β-cell in the pathogenesis of type 2 diabetes mellitus [J]. Am J Med,2000, 108(suppl 6a):2S-8S.
  • 6Butler AE, Janson J, Bonner-Weir S, et al. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes [J]. Diabetes, 2003, 52(1):102-10.
  • 7Butler AE, Janson J, Soeller WC, et al. Increased beta-cell apoptosis prevents adaptive increase in betacell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid [J]. Diabetes, 2003, 52(9):2304-14.
  • 8Mandrup-Poulsen T. Apoptotic signal transduction pathways in diabetes [J]. Biochem Pharmacol, 2003, 66(8): 1433-40.
  • 9Robertson RP, Harmon J, Tran PO, et al. β-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes [J]. Diabetes, 2004, 53 (Suppl1):S119 - 24.
  • 10Peruzzi F, Prisco M, Dews M, et al. Pleiotropic effects of fatty acids on pancreatic β-cells [J]. J Cell Physiol,2002, 194 (1):1 - 12.

共引文献49

同被引文献91

引证文献17

二级引证文献48

中国老年学杂志
2009年 第4期

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