摘要
目的探讨^18F—FDG与^11C—MET PET—CT显像对常规磁共振成像（MRI）不易鉴别的环形强化脑肿瘤与非肿瘤性病变的鉴别诊断价值。方法对41例病史及临床体征不典型、MRI上呈相似明显环形强化的脑内病变患者，分别行^18F—FDG及^11C-METPET—CT头部扫描，其中15例不除外脑转移瘤者加行^18F—FDGPET—CT体部扫描，并对扫描结果进行视觉分析和半定量分析。经病理或临床证实为肿瘤性病变30例，非肿瘤性病变11例。结果视觉分析结果显示，^18F-FDGPET-CT正确诊断肿瘤性病变16例，假阴性14例，假阳性3例，诊断的敏感度、特异度和准确度分别为53．3％、72．7％和58．5％。9例脑转移瘤均通过体部扫描准确发现了肿瘤原发灶。^11C—METPET．CT正确诊断肿瘤性病变29例，假阴性和假阳性各1例，诊断的敏感度、特异度和准确度分别为96．7％、90．9％和95．1％。半定量分析结果显示，高度恶性脑肿瘤的L/WMFDG和L／WMMET均明显高于低度恶性脑肿瘤和非肿瘤性病变（均P〈0．01），低度恶性脑肿瘤与非肿瘤性病变间仅L／WMMET的差异有统计学意义（P〈0．01），转移瘤和胶质母细胞瘤间L／WMFDG和L／WMMET的差异均无统计学意义（均P〉0．05）。结论^18F-FDG和^11C—METPET—CT在鉴别MRI环形强化脑肿瘤中均有一定的价值，^11C—METPET-CT更有助于低度恶性肿瘤与非肿瘤性病变的鉴别，而^18F—FDGPET—CT体部扫描有助于脑转移瘤的诊断；两种届像剂群合估用能摇高对环形样化腩肿瘤诊斯的准确痔，
Objective To evaluate the value of ^18F-FDG and ^11C-MET PET-CT scan in differentiation of brain ringlike-enhanced lesions on MRI imaging. Methods Forty-one brain ringlikeenhanced lesions on MRI imaging including 30 brain tumors and 11 non-neoplastic lesions confirmed pathologically or clinically underwent ^18F-FDG and ^11C-MET PET-CT brain scan. Among them, 15 patients who were suspected to have brain metastasis received body scan by ^18F-FDG PET-CT. Both images were analyzed visually and semi-quantitatively. Results Visual analysis： for brain tumors the diagnostic sensitivity, specificity and accuracy of ^18F-FDG PET-CT was 53.3%, 72.7% , 58.5% , versus 96.7% , 90.9%, 95.1% of ^11 C-MET PET-CT, respectively. All the primary foci in 9 patients with brain metastases were detected by body is F-FDG PET-CT scan. Semiquantitative analysis： There was a significant difference in the uptake between highly differentiated malignant and poorly differentiated tumors as well as nonneoplastic lesions for both tracers （ P 〈0.01 ） , while between low-grade malignant tumors and non-neoplasm lesions, there was a difference in uptake only by ^11C-MET （P 〈 0.01 ）. No significant difference between the uptakes in brain metastasis and glioblastomas was found by both tracers （P 〉 0.05）. Conclusion Both ^18F-FDG and ^11C-MET PET-CT are useful in differentiation of brain ringlike-enhanced lesions on MRI imaging. 11C-MET PET-CT is more helpful than ^18F-FDG PET-CT in differential diagnosis of low-grade neoplastic from non-neoplastic lesions. Combination of ^18F-FDG and ^11 C-MET PET-CT scans can improve the accuracy of differential diagnosis for brain ringlike-enhanced lesions on MRI imaging.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2009年第2期134-138,共5页
Chinese Journal of Oncology
