摘要
目的评价奎硫平治疗躁狂症的疗效以及与对照组间的差异。方法应用循证医学方法对符合标准的15项研究进行分析,评价奎硫平与对照组治疗躁狂症的有效率、痊愈率的差异。结果奎硫平组与安慰剂的3周、12周有效率有非常显著性差异(P<0.01),3周、12周痊愈率同样存在非常显著性差异(P<0.01)。在应用心境稳定剂的基础上与安慰剂的对照比较也发现,3周和6周的有效率与痊愈率均非常显著高于安慰剂组(P<0.01),但是与传统抗精神病药物、氯氮平以及心境稳定剂的有效率、痊愈率以及症状改善率均没有显著性差异(P>0.05)。结论奎硫平治疗躁狂症是一种良好的药物,联合心境稳定剂效果更好。
Objective To assess the difference between Quetiapine and control in treatment of mania. Methods 15 studies meeting our criteria were analyzed by based - evidence medicine, comparing the difference in efficacy rate, full remission rate. Results The very significant differences in both effective rate and full remission rate at 3rd weekend and 12th weekend were found between Qietiapine and placebo （P 〈 0. 01 ） . In the basis of combining with mood stabilizers, Quetaipine groups had significant higher rates of efficacy rate and full remission rate than that of placebo groups in treatment of mania （P 〈0. 01 ） . No difference in efficacy rate, full remission rate and symptoms changing rate between Quetiapine and typical antipsychotics, clozapine, mood stabilizers （P 〉 0. 05） . Conclusion It is a better therapy for patients with mania, especially, Quetiapine combining with mood stabilizers.
出处
《国际精神病学杂志》
2009年第1期4-8,共5页
Journal Of International Psychiatry
