摘要
目的:探讨利培酮联合小剂量氯氮平治疗难治性精神分裂症(TRS)的疗效及安全性。方法:选取2007年1月至2008年1月间在我院住院治疗的TRS患者90例,随机分为治疗组和对照组,对照组给予单纯利培酮治疗,治疗组在此基础上联合小剂量的氯氮平治疗。结果:各组治疗后PANSS总分改善明显优于治疗前,两者比较差异具有统计学意义(P<0.05)。治疗后1周、2周治疗组PANSS总分改善明显优于对照组,两者比较差异具有统计学意义(P<0.05)。治疗组总有效率为86.67%,对照组为80.00%,两者比较差异无统计学意义(P>0.05)。治疗组锥体外系反应、失眠发生率明显低于对照组,心动过速发生率明显高于对照组,两者比较差异均具有统计学意义(P<0.05)。结论:利培酮联合小剂量的氯氮平治疗难治性精神分裂症起效快,疗效好,治疗安全。
Objective： To invesigate the clinical efficacy and safety of risperidone combining low dosage clozapine treatment in the patients with treatment - resistant schizophrenics. Method： 90 cases with treatment - resistant schizophrenics were selected in our hospital from January in 2007 to January in 2008. All of them were divided into treatment group and control group randomly, the patients in control group received the treatment of risperidone, and who in control group received the treatment of risperidone combining low dosage of clozapine. Result： The total scores of PANSS in two groups after treatment were less than that before treatment, there was significent difference between two groups （ P 〈 0.05 ）. In the time of 1 week and 2 weeks, the total scores of PANSS in treatment groups was less than that in control group, there were significant difference between two groups（ P 〈0.05 ）. The total effective rate was 86.67% in treatment groups and 80. 00% in control group, there was no significant difference between two groups （ P 〉 0.05 ）. The incidence rate of untoward reaction of extracorticospinal tract and insomnia in treatment group were less than that in control group, and the incidence rate of tachycardia was more than that in control group, there were significant difference between two groups respectively （ P〈 0.05 ）. Conclusion： The clinical efficacy of risperidone combining low dosage of clozapine treatment in patients with treatment - resistant schizophrenics is obvious, quick and safe.
出处
《河北医学》
CAS
2009年第2期133-136,共4页
Hebei Medicine
关键词
利培酮
氯氮平
难治性
精神分裂症
Risperidone
Clozapine
Treatment - resistant
Schizophrenics
