摘要
目的探讨近年来鲍曼不动杆菌的临床分布特点及耐药性变化情况,指导临床用药。方法对本院2004年1月-2007年12月临床分离鲍曼不动杆菌标本来源、分布科室及药敏试验结果进行回顾性分析。结果4年来检出鲍曼不动杆菌322株,标本来源主要为患者的痰液,其次为脓液及分泌物,科室分布以ICU最高;鲍曼不动杆菌的耐药率在4年中总体呈上升趋势。其中头孢西丁、阿莫西林和头孢呋辛的耐药率处于很高水平,其耐药率上升到95%以上;耐药率上升幅度较大的药物有头孢吡肟、哌拉西林/三唑巴坦,它们的耐药率从2004年的47.0%和47.1%上升到68.4%和79.5%。而目前治疗该菌的最有效抗生素亚胺培南和美洛培南的耐药率也上升至约20%。结论4年来鲍曼不动杆菌多重耐药率逐年增高,应加强对鲍曼不动杆菌耐药谱及其动态变化的检测,合理使用抗菌药物,减少及延缓该菌耐药性进一步发生,避免院内感染暴发流行。
Objective To investigate the character of clinical distribution and the varied situation of drug-resistance of acinetobacter baumannii to guide the clinical use of it. Methods The clinical seperation of the specimen source of acinetobacter baumannii,the distribution of technical offices and the result of drug sensitivity test from Jan.2004 to Dec.2007 in our hospital were analysed. Results A total of 322 strains of acinetobacter baumannii were isolated in the past four years,the main source of specimen was phlegm from patients,and then was liquid and secretion,the number of specimen from ICU was the highest among all the technical offices;the drug-resistant percentage of acinetobacter baumannii in the past four years presented an increasing tendency.And it was also in a high level of Cefoxitin,Amoxicillin and Cefuroxime,more than 95%;and Cefepime,Piperacillin/tazobactam also had a high increasing gin,raising from 47.0%,47.1% in 2004 to 68.4%,79.5% in 2007 respectively.While the drug-resistant percentage of Imipenem,meropenem,which are the most effective interferon to treat this bacteria at present,is nearly 20%. Conclusion In the past four years,rate of drug-resistance of discovered acinetobacter baumannii has been higher,so it＇s necessary to strengthen the test of its drug-resistant dissemination and dynamic change,use interferon reasonably,decrease and delay the growth of its drug-resistance,avoid breaking out a boom of bacterial infection in the hospital.
出处
《南华大学学报（医学版）》
2008年第5期646-648,共3页
Journal of Nanhua University(Medical Edition)
关键词
鲍氏不动杆菌
耐药性
抗菌药物
Acinetobacter baumannii
drug resistance
antibiotic
