摘要
目的:检测癌相关抗原125(A125)在胃癌腹膜转移病人血清中的表达状况并探讨其在胃癌腹膜转移中的诊断意义。方法:选择经病理证实的70例胃癌患者为研究对象,其中胃癌腹膜转移者和无腹膜转移者各35例,手术前一周用放射免疫法检测其血清中CA125含量,同时测定肿瘤相关抗原CA19-9和CEA作参照,术前常规行腹部B超或CT检查。剖腹探查时观察腹膜转移的部位、范围、数目及大小等。健康对照30例。结果:胃癌组血清CA125水平明显高于对照组(P<0.05)。在35例出现腹膜转移的胃癌患者中,血清CA125水平超过正常值(35U/ml)者有28例(80%),范围从87U/ml～480U/ml,其数值与腹膜转移的程度成正比;而无腹膜转移组的35例患者,只有1例血清CA125水平略有升高(47U/ml),两组间存在显著差异(P<0.01)。结论:血清CA125水平可作为胃癌腹膜转移有效的预测指标,CA125水平在出现腹膜转移的胃癌患者血清中显著升高,并提示预后不良。
Objective： To examine the level of serum carbohydrate antigen 125 （CA 125） in patients with gastric cancer and to investigate the clinical value of serum CA125 in prediction of peritoneal dissemination in gastric cancer. Methods： We addressed the clinic predictability significance of the levels of serum CA125 in peritoneal dissemination in patients （n=35） with gastric adenocarcinomas and matched non-peritoneal dissemination （n=35）. CA125 was examined by using immunoradiometric assay within one week before opera- tion. Meanwhile, CA19-9 and CEA were measured in the same samples. Abdominal computed tomography （CT） or ultrasonography were the rout examination before operation. Then, we observed the site, area, number and size of peritoneal dissemination during operation. Another 30 healthy volunteer was invited as control. Results： The level of CA 125 were significantly higher in patients with gastric adeno- carcinomas than that of normal control group （P〈0.05）. The level of CA125 was increased in most of the patients （28/35, 80%） with peri- toneal dissemination （range 87 U/ml-480 U/ml ）, however, the elevated level of CA125 in patients with non-peritoneal dissemination was only detected in 1 case （47 U/ml）. Moreover, increased CA125 level in patients with peritoneal dissemination correlated with extent of peritoneal metastasis. Conclusion The serum CA 125 level may serve as a valid index in predicating peritoneal metastases in patients with gastric carcinoma. Increased CA 125 level in patients with peritoneal dissemination indicated a poor prognosis.
出处
《现代生物医学进展》
CAS
2009年第5期911-913,共3页
Progress in Modern Biomedicine
关键词
糖类抗原125(CA125)
胃癌
腹膜转移
Carbohydrate antigen 125 （CA125）
Gastric carcinoma
Peritoneal dissemination
