摘要
【目的】探讨对反复呼吸道感染(recurrent respiratory tract infection,RRI)患儿进行免疫球蛋白和Th1/Th2类细胞因子检测的临床意义。【方法】观察30例RRI患儿治疗前后外周血IgGI、gAI、gMI、L-4和IFN-γ的含量变化,并与30例健康体检儿童对照比较。【结果】治疗前,RRI组儿童IgG、IgA、IgM含量均明显低于健康对照组(P<0.05),IL-4含量明显高于健康对照组(P<0.01),IFN-γ含量明显低于健康对照组(P<0.01)。治疗后,与治疗前比较,RRI组儿童IgGI、gAI、gM含量均明显上升(P<0.05),RRI组儿童IL-4含量明显下降(P<0.01),IFN-γ含量明显升高(P<0.01)。【结论】RRI患儿存在体液免疫低下和细胞免疫失调,临床可以通过检测RRI患儿外周血IgG、IgA、IgMI、L-4和IFN-γ含量,作为评价病情严重程度的参考依据和临床终止治疗的参考指标。
【Objective】 To investigate the clinical significance of detection of immunoglobulin and Th1/Th2 in children with recurrent respiratory tract infection(RRI). 【Methods】 Levels of IgG,IgA,IgM,IL-4 and IFN-γ in peripheral blood were measured in 30 cases of children with RRI before and after treatment,and compared with those in the control group. 【Results】 Before treatment,the levels of IgG,IgA and IgM in RRI group were lower than those of the control group respectively(P<0.05).The content of IL-4 was significantly higher than that of the control group(P<0.01),while IFN-γ was significantly lower(P<0.01).After treatment,the levels of IgG,IgA and IgM in RRI group were increased significantly(P<0.05),IL-4 apparently decreased(P<0.01) and IFN-γ increased significantly(P<0.01). 【Conclusion】 The depression of humoral immunofunction and maladjustment of cellular immunofunction were observed in children with RRI.Clinically,detection of the levels of IgG,IgA,IgM,IL-4 and IFN-γ in the peripheral blood from children with RRI could be taken as a predictive marker for disease severity and reference marker for therapy termination.
出处
《中国儿童保健杂志》
CAS
2009年第2期204-206,共3页
Chinese Journal of Child Health Care
