摘要
目的考察微乳、微囊、脂质体不同微型药物载体对扑热息痛体外经皮渗透的影响。方法使用Franz体外释药装置,采用紫外分光光度法检测接受液中扑热息痛的浓度并计算药物的经皮累积释放量。结果在体外经皮释放试验中,扑热息痛经皮制剂的不同给药载体经皮吸收效果差异明显,不同给药载体经皮吸收试验的体外渗透参数表明,脂质体和微囊的经皮吸收效果明显优于微乳,差异有统计学意义（P〈0.05）。结论微囊更适宜作为扑热息痛经皮制剂的给药载体。
Objective To investigate the effects of different microcarriers for percutaneous absorption of paracetamol through rat＇s skin in vitro. Methods Differrent percutaneous micro - carrier systems, including microemulsion, microcapsules, and lipo- somes, were prepared. Modified Franz apparatus was used to study the transdermal cumulative amount of the drug determined by ultra- violet spectrophotometry through rat＇ s skin in vitro. Results The＇effect of different carriers for percutaneous absorption of paracetamol through rat＇ s skin in vitro was different. The parameter of permeation shows that the effect of liposome and microcapsule are significant- ly better than that of micromulsion （P 〈 0.05）. Conclusions Microcapsule is superior dosage carrier of paracetamol.
出处
《武警医学》
CAS
2009年第3期235-237,共3页
Medical Journal of the Chinese People's Armed Police Force
基金
武警医学院科研基金(WYQ2005-9)
关键词
扑热息痛
微乳
微囊
脂质体
Paracetamol Microemulsion Microcapsule Liposome
