摘要
目的探讨血清超敏C反应蛋白(hs-CRP)在妊娠糖尿病(GDM)患者发病中的作用。方法利用ELISA方法检测51例妊娠糖尿病患者和45例糖耐量正常(NGT)孕妇的血清hs-CRP水平,采用葡萄糖氧化酶法及放射免疫法测定空腹葡萄糖(FPG)、空腹胰岛素(FIns)水平,计算胰岛素抵抗指数(HOMA-IR)。结果(1)GDM组FPG[(6.09±0.79)mmol/L]、FIns[(17.03±7.58)mIU/L]、HOMA-IR(3.88±2.01)、hs-CRP[(11.07±3.69)mg/L]分别高于NGT组[(4.30±0.50)mmol/L、(13.39±3.17)mIU/L、(2.56±0.69)和(6.08±2.54)mg/L](P<0.01);(2)血清hs-CRP水平与HOMA-IR(r=0.288,P<0.01)、FIns(r=0.301,P<0.01)、BMI(r=0.196,P<0.01)相关。结论慢性炎症与胰岛素抵抗密切相关,hs-CRP升高是GDM的发病的一个预测因子。
Objective To explore the clinical significance of detecting serum high- sensitivity C- reactive protein （hs - CRP） levels in patients with gestational diabetes mellitus （GDM）. Methods Fifty - one patients with GDM and 45 pregnant women with normal glucose tolerance （NGT） were observed. ELISA was used to evaluate serum hs- CRP level. Fasting plasma glucose （FPG） and fasting insulin （Fins） were measured by oxidized assay and immunoradioassay. Insulin resistance index （HOMA- IR） was calculated. Results The levels of FPG, Fins, HOMA- IR and hs - CRP in GDM group [ （6.09 ± 0.79）mmol/L, （ 17.03 ± 7.58）mlU/L, （3.88 ± 2.01 ）, and （ 11.07 ± 3.69） mg/L] were significantly higher than those of normal group E（4.30 ± 0.50）mmol/L, （13.39 ± 3.17）mlU/L, （2.59 ± 0.69）, and （6.08 ± 2..54）mg/L] （P〈0.01）. Circulation level of hs-CRP was correlated with HOMA- IR （r=0.288, P〈0.01）, Fins（r=0.301, P〈0.01）, and BMI（r=0. 196, P 〈 0.01）. Conclusions The data support the hypothesis that low grade systemic inflammation is closely related to insulin resistance, hs- CRP is a strong predictor for the development of GDM.
出处
《实用预防医学》
CAS
2009年第2期339-340,共2页
Practical Preventive Medicine
基金
深圳市科技和信息局资助课题(200602037)
关键词
妊娠糖尿病
超敏C反应蛋白
胰岛素抵抗
Gestational diabetes mellitus
High sensitive C- reactive protein
Insulin resistance
