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The Effect of GHRH, GHRP-2 and Somatostatin on GH Secretion by fetal pituitary 被引量：3

The Effect of GHRH, GHRP-2 and Somatostatin on GH Secretion by fetal pituitary
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摘要 Growth hormone releasing peptide (GHRP-2) is a synthetic hexapep-tide which specifically stimulates secretion of growth hormone (GH) by fetal pitu-itary somatotrophs through a new membrane receptor, which is different from growth hormone releasing hormone (GHRH) and somatostatin (SMS) receptors.We used cell cultures of human fetal pituitary somatotroph cells to investigate the effect of GHRH, GHRP-2 and somatostatin on GH secretion. The results showed that the mechanism of GHRH/SMS and GHRP-2 was different- This indicated that a different intracellular signal transduction system might also play a crucial role in the regulation of GH secretion. Growth hormone releasing peptide (GHRP-2) is a synthetic hexapep-tide which specifically stimulates secretion of growth hormone (GH) by fetal pitu-itary somatotrophs through a new membrane receptor, which is different from growth hormone releasing hormone (GHRH) and somatostatin (SMS) receptors.We used cell cultures of human fetal pituitary somatotroph cells to investigate the effect of GHRH, GHRP-2 and somatostatin on GH secretion. The results showed that the mechanism of GHRH/SMS and GHRP-2 was different- This indicated that a different intracellular signal transduction system might also play a crucial role in the regulation of GH secretion.
作者 刘勤 白祥军 刘暌 林雯 雷霆
出处 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 1999年第4期277-279,共3页 华中科技大学学报（医学英德文版）
关键词 fetal pituitary GH GHRP-2 GHRH SOMATOSTATIN fetal pituitary GH GHRP-2 GHRH somatostatin
分类号 R321.5 [医药卫生—人体解剖和组织胚胎学]
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同被引文献18

  • 1雷霆,刘勤,李洛,张龙,舒凯,薛德麟.Preliminary Study on the Relationship between cAMP Level and gsp Expression in Cultured Human Pituitary Somatotrophinomas[J].Journal of Huazhong University of Science and Technology(Medical Sciences),2000,20(3):214-216. 被引量：1
  • 2张华楸,王雄伟,范月超,王和平,叶飞,雷霆.“交叉通讯”在人垂体生长激素腺瘤激素分泌中的调控作用研究[J].微循环学杂志,2005,15(2):11-14. 被引量：4
  • 3Yoshimasa T,Sibley D R,Bouvier M et al.Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation. Nature . 1987
  • 4Lei T,Adams E F,Buchfelder M et al.Relationship between protein kinase C and adenylyl cyclase activity in the regulation of growth hormone secretion by human pituitary somatotrophinomas. Neurosurgery . 1996
  • 5Frutos MG,Cacicedo L,Méndez CF,et al.Pituitary al- terations involved in the decline of growth hormone gene expression in the pituitary of aging rats[].Journals of Gerontology Series A Biological Sciences and Medical Sciences The.2007
  • 6Zhao D.Protein kinase cdelta-mediated CREB activation regulates ghrelin-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colonic epithelial Cells[].Journal of Cellular Biochemistry.2007
  • 7Casanueva FF,Camia JP,Carreira MC,et al.Growth hormone-releasing hormone as an agonist of the ghrelin receptor GHS-R1a[].Proceedings of the National Academy of Sciences of the United States of America.2008
  • 8Howard A D,Feighner S D,Cully D F,et al.A receptor in pituitary and hypothalamus that functions in growth hormone release[].Science.1996
  • 9Lei T,Adams EF,Buchfelder M,et al.Relationship between protein kinase C and adenylyl cyclase activity in the regulation of growth hormone secretion by human pituitary somatotrophinomas[].Neurosurgery.1996
  • 10van der Lely AJ,Tscop M,Heiman ML,et al.Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin[].Endocrine Reviews.2004

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Journal of Huazhong University of Science and Technology(Medical Sciences)
1999年 第4期

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