摘要
目的：研究乙肝Ⅰ号方对实验性急性肝损伤小鼠抗氧自由基损伤的作用及其机制。方法：采用ｄ－氨基半乳糖急性肝损伤模型，观察小鼠肝匀浆丙二醛（ＭＤＡ）含量、超氧化物歧化酶（ＳＯＤ）及血清酶学改变。结果：乙肝Ⅰ号方防治组与对照组相比，小鼠肝损伤明显减轻，肝匀浆ＭＤＡ含量下降，血清ＡＬＴ降低，降低程度与用药量呈明显的量效关系，且抗氧自由基作用优于乙肝灵冲剂。
Objective:Prescription No 1 for anti-hepatitis B(P1AHB),was studied for its antioxidation in experimental hepatic injury.Method:The acute hepatic injury was induced by peritoneoinjection with d-galactosamine in mice.The liver tissue and blood samples were taken and measured for the level of malonyldialdehyde(MDA),and for the change of superoxide dismutase (SOD) in liver and serum glutamic pyruvic transaminase (SGPT) in blood.Result:Compared with control animals,P1AHB can dose-dependently inhibit the increased MDA in liver and SGPT in blood.Therefore the hepatic injury was alleviated.Conclusion:It is suggested that the therapeutical action of P1AHB on hepatitis B be associated with its antioxidation
出处
《南京铁道医学院学报》
1998年第1期7-9,共3页
Journal of Nanjing Railway Medical College
基金
江苏省省科委课题
关键词
谷丙转氨酶
丙二醛
乙型肝炎
中医药疗法
hepatic injury
malonyldialdehyde
superoxide dismutase
glutamic pyruvic transaminase
