摘要
目的:探讨有效治疗急性胰腺炎脑损伤的新药物。方法:采用逆行胰胆管注射牛磺胆酸钠制成大鼠急性胰腺炎模型,将必存溶于生理盐水,在建模后1小时注入大鼠股静脉,制模后3小时、6小时、12小时检测脑组织的镜下病理学评分、iNOS。结果:所有治疗组模型经治疗后脑组织的镜下病理学评分、iNOS均有所改善。结论:必存对急性胰腺炎大鼠脑损伤有明显的保护作用。
Objective： To explore a new drug to treat acute pancreatitis--associated brain injury. Methods： Acute pancreatitis--associated brain injury was induced in rats by retrograde injection of TCA into biliopancreatie ducts. Edara- vone was dissolved in physiological saline and injected intravenuously into the model of Sprague--Dawley rats. The brain injury were measured by iNOS activity and histopathologic scoring in 3 hours, 6 hours and 12 hours after the brain injury modelling. Result： Treatment with edaravone led to marked reductions in iNOS activity and histopathologie scoring. Conclusion： Edaravone can effectively protect brain with acute pancreatitis--associated brain injury.
出处
《包头医学院学报》
CAS
2009年第2期131-132,135,共3页
Journal of Baotou Medical College
关键词
必存
急性胰腺炎
脑损伤
Edaravone, Acute panereatitis
Brain injury
