摘要
在大鼠玻璃体内注射脑源性神经营养因子（ＢＤＮＦ）或正常羊血清（对照），观察对急性高眼压后视网膜电图的影响。急性高眼压后３天，实验组视网膜电图ｂ波恢复程度明显高于对照组（Ｐ＜０．０１）。
Brain-derived neurotrophic factor(BDNF) or normal goat serum(NGS) was injected intravitreously in each 11 wistar albino rats two days before the induction of ischemia. Retinal ischemia was induced in 22 rats by increasing intraocular pressure to the threshold level which extinguished the electroretinography(ERG) b-wave individually, and maintaining for 90 minutes. The ERG b-wave of the BDNFtreated rats recovered to 80.5±24.4% of their normal amplitude three days after ischemia, while that of the NGStreated rats recovered only to 11.1±5.3%. Statistic analysis showed that the recovery level of ERG bwave after ischemia in the BDNF and NGS treated rats was significantly different (P<0.01). The results suggest that BDNF could promote the recovery of the retinal electrophysiologic function from ischemia induced by high intraocular pressure.
出处
《湖南医科大学学报》
CSCD
1998年第2期123-125,共3页
Bulletin of Hunan Medical University
基金
国家自然科学基金
关键词
高眼压损伤
神经营养因子
视网膜电图
BDNF
brain-derived neurotrophic factor*
electroretinography
ocular pressure
rat
