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多西他赛联合顺铂治疗50例非小细胞肺癌的疗效观察 被引量:1

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摘要 目的探讨多西他赛联合顺铂对非小细胞肺癌(NSCLC)的临床疗效。方法对5O例NSCLC患者给予DP方案化疗:多西他赛75mg/m2,静脉滴注,d1;顺铂75mg/m2,静脉滴注,d1;21d为1个周期,每例至少化疗2个周期以上。结果本组5O例中完全缓解(CR)2例,部分缓解(PR)24例,无变化(SD)21例,进展(PD)3例,总有效率(CR+PR)为52%。不良反应以骨髓抑制及消化道反应为主,大部分患者经过对症治疗后可恢复正常。对于个别骨髓抑制严重患者,化疗时间适当延后或用粒细胞集落刺激因子后按时进行化疗。未出现严重的肝肾功能损害、水钠潴留、过敏反应和心脏损害,无化疗相关性死亡病例。结论多西他赛联合顺铂治疗晚期NSCLC疗效较好,不良反应可耐受,可作为一、二线用药治疗方案。
出处 《中国实用医药》 2009年第11期125-126,共2页 China Practical Medicine
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