摘要
细菌通过自身合成的水合多聚物粘附在固体表面,以固着的方式生长从而形成生物膜,细菌生物膜的形成涉及到几个明显的阶段,包括起始的附着、细胞与细胞之间的吸附与增殖、生物膜的成熟、及最后细菌的脱离等四个阶段,生物膜的形成增加了细菌对抗生素的抗性以及帮助细菌逃逸寄主的免疫攻击等,从而引起临床上持续性的慢性感染等各种问题;生物膜结构非常复杂,除了细菌分泌的各种胞外多糖,胞外蛋白质外,最新的研究表明,DNA也是生物膜的一个重要成分。针对近年来的最新文献报道分别对生物膜的形成、结构以及调控机制等进行综述。
Bacterial biofilms are structured communities of cells enclosed in self-produced hydrated polymeric matrix adherent to an inert or living surface. The formation of biofilms involves several distinct stages, including initial attachment, cell-to-cell adhesion and proliferation, mat- uration, and finally detachment. Formation of these sessile communities and their inherent resistance to antibiotics and host immune attack is the root of many persistent and chronic bacterial infections. The matrix of bacterial biofilms is a complex mixture of macromolecules including exopolysaccharides, proteins and DNA. The formation, structure and regulation mechanisms of biofilms will be reviewed in this text.
出处
《生物学杂志》
CAS
CSCD
2009年第2期48-50,53,共4页
Journal of Biology
基金
“十一五”国家科技支撑计划重大项目“食品安全关键技术”子课题(2006BAK02A19)
中国博士后专项基金
关键词
细菌生物膜
形成
结构
调控机制
bacterial biofilms
formation
structure
regulation mechanism
