摘要
目的探讨癫患者事件相关电位(ERP)和血浆单胺类神经递质水平的改变及其相关性。方法对50例癫患者进行ERP和血浆去甲肾上腺素(NE)、多巴胺(DA)和5-羟色胺(5-HT)水平检测,并与正常对照组比较。结果与正常对照组比较,癫组ERP的N2、P3波潜伏期延长,P3波幅明显降低(均P<0.01),血浆NE、DA和5-HT水平显著降低(均P<0.01)。癫组ERP的P3波潜伏期与血浆NE、DA和5-HT水平呈负相关(r=-0.33,r=-0.41,r=-0.46,均P<0.01),P3波幅与其呈正相关(r=0.32,r=0.39,r=0.48,均P<0.01)。结论癫患者有ERP异常和血浆单胺类神经递质水平降低;并且ERP异常程度与血浆单胺类神经递质水平相关。
Objective To explore the changes and their correlation of event-related potential （ERP）and the plasma levels of monoamine ＇neurotransmitter in the patients with epilepsy. Methods ERP and the plasma levels of noradrenalin （ NE ）, dopamine （ DA ） and 5-hydroxytryptamine （5-HT） were tested in 50 patients with epilepsy, and the results were compared with the normal controls. Results The latency of N2, P3 of ERP and the amplitude of P3 in the epilepsy group were significant longer and lower than those in the normal control group（ all P 〈 0. 01 ）. The plasma levels of NE,DA and 5-HT in the epilepsy group were significant lower than those in the normal contral group（ all P 〈 0. 01 ）. Correlation analysis showed that there were negative correlation with latency of P3 of ERP and the level of NE , DA and 5-HT in epilepsy group （ r = - 0. 33, r = - 0.41, r = - 0. 46, all P 〈 0.01 ）, and positive correlation with P3 amplitude respectively （ r = 0. 32, r = 0. 39, r = 0.48, all P 〈 0. 01 ）. Conclusion Epilepsy patients have abnormal ERP and the plasma levels of monoamine neurotransmitter decrease, and the degree of abnormal ERP are correlated with the plasma levels of monoamine nenrotransmitter.
出处
《临床神经病学杂志》
CAS
北大核心
2009年第2期102-104,共3页
Journal of Clinical Neurology
关键词
癫痫
事件相关电位
单胺类神经递质
epilepsy
event-related potential
monoamine neurotransmitter
