摘要
目的:探讨短期丰富生存环境对中老年大鼠空间学习能力的作用及性别差异。方法:将14月龄的Sprague-Dawle(ySD)大鼠分雌、雄性后再随机分为丰富生存环境组与空白对照组,前者在丰富生存环境条件下饲养,后者在普通环境下饲养,4个月后分别测试在Morris水迷宫中的成绩。结果:短期丰富生存环境下,雌性大鼠的空间学习能力显著强于空白对照组,而同样条件干预的雄性大鼠空间学习能力与空白对照组相比无显著性差异。另外,在普通环境中饲养4个月的雄性大鼠空间学习能力明显强于雌性大鼠,而丰富生存环境条件下雌、雄性大鼠空间学习能力相比无显著性差异。结论:中老年雄性大鼠空间学习能力强于雌性大鼠,但中老年雌性大鼠大脑功能的可塑性可能要强于雄性大鼠,短期丰富生存环境的干预对于中老年雌性大鼠空间学习能力有显著性影响。本研究结果为将来寻找延缓大脑衰老过程的行为学手段提供了重要的理论依据。
Objective： To investigate the effects of the short-term enriched environment on the spatial learning capacity of middle-aged rats and to figure out if the effects are sex dependent. Methods ： 14-month old male and female Sprague-Dawley rats were randomly divided into enriched group and standard group. Enriched rats were reared in enriched environment and standard rats were reared in standard environment for 4 months prior to the assessment in Morris water maze. Results： Compared with the standard environment, enriched environment could only promote the spatial learning capacity of the middle-aged female rats. The spatial learning capacity of standard male rats was superior to that of the standard females ; however, the spatial learning capacity of enriched male rats was equal to that of the enriched females. Conclusion： Short-term enriched environment remarkably improved the spatial learning capacity of middle-aged female rats. The spatial learning capacity of middle-aged male rats was better than female rats, but the plasticity of the brain function in middle-aged female rats may be better than that in male rats. The results in the present study provide an important theoretical basis for the future study that searches for behavioral strategy to postpone the progress of brain aging.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2009年第5期521-524,共4页
Journal of Chongqing Medical University
基金
国家自然科学基金(30440082
30572075)
国家人事部2005年度高层次留学人才回国工作资助经费
教育部重点科研项目
教育部留学人员科研启动基金
重庆市自然科学基金(CSTC
2005BB5034)。
