摘要
目的：观察牛磺酸加泛癸利酮治疗病毒性心肌炎（ＶＭＣ）的疗效。方法：ＶＭＣ９５例在用泛癸利酮２０ｍｇ，ｐｏ，ｔｉｄ基础上分为３组：（１）加牛磺酸组３０例，给牛磺酸２ｇ，ｐｏ，ｔｉｄ；（２）加牛磺酸及抗心律失常药物组３０例，给牛磺酸服法同上，另外加普罗帕酮１５０ｍｇ，ｐｏ，ｔｉｄ或美西律１５０ｍｇ，ｐｏ，ｔｉｄ；（３）对照组３５例，给极化液（５％葡萄糖５００ｍＬ＋１０％氯化钾１０ｍＬ＋胰岛素８Ｕ）静脉滴注，ｑｄ×２ｗｋ后改用维生素Ｃ０．２ｇ，ｐｏ，ｔｉｄ。３组疗程依次为４．０±１．０ｍｏ，３．０±２．０ｍｏ及６±３ｍｏ。结果：临床症状、肠道病毒核糖核酸转阴率及早搏减少的总有效率，３组依次为８７％，７９％，９０％；９３％，７８％，９５％％；６３％，４３％，６０％。前２组优于对照组（Ｐ＜０．０５）。结论：牛磺酸加泛癸利酮对ＶＭＣ有较好疗效。
AIM: To observe the effect of taurine on the treatment of patients with viral myocarditis(VMC). METHODS: Patients with VMC 95 were divided into 3 groups: Taurine group 30 patients (M 16, F 14; age 35±s 12 a)were treated with taurine 2g, po, tid and ubidecarenone 20 mg, po, tid, course of treatment 4.0±1.0 mo. Among them 30 patients (M 18, F 12, age 33±13 a) were treated with propafenone 150 mg, po, tid or mexiletine 150 mg, po, tid besides taurine and ubidecarenone, course of treatment 3.0±2.0 mo; The another 35 patients(M 16, F 19, age 34±11 a) were treated with 5% glucose 500 mL, insulin 8 U, 10% potassium chloride 10 mL, iv drip qd ×2 wk, then changed to ascorbic acid 0.2 g, po, tid, and ubidecarenone 20 mg, po tid, course of treatment 6±3 mo. RESULTS: After 3 mo by treatment, the total response rate in improving clinical symptoms, negative of enterovirus ribonucleic acid(EVs_RNA)in blood cells and reduction of extrasystole by 24 h Holter monitoring were 87%,79%,90%;93%,78%,95%;and 63%,43%,60% respectively, in above 3 groups, the front 2 groups are superior to the latter group (P< 0.05 or 0.01). CONCLUSION: Taurine plus ubidecarenone is a better drug in the treatment of patients with VMC.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
1998年第2期83-85,共3页
Chinese Journal of New Drugs and Clinical Remedies
关键词
牛磺酸
泛癸利酮
病毒性心肌炎
taurine
benzoquinones
ubidecarenone
propafenone
mexiletine
potassium chloride
insulin
myocarditis
virus diseases
combination drug therapy
