期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

破骨细胞在类风湿关节炎骨破坏中的研究进展 被引量：1

原文传递
导出
摘要 慢性滑膜炎伴关节软骨和骨的破坏是类风湿关节炎（rheumatoid arthritis，RA）的基本特征，而骨的破坏直接导致畸形和伤残。目前越来越多的证据表明：破骨细胞在骨的侵蚀过程中起着核心作用。对核因子（NF）-κB受体激活剂配基（RANKL）基因或c-fos基因进行敲除，或者使用骨保护素（OPG），可以使动物模型缺乏成熟的破骨细胞，虽然局部炎症可以很严重，但是却不会发生骨的侵蚀。这些动物实验表明，炎症不一定导致骨的破坏，只有在破骨细胞存在的情况下才会发生骨的破坏。本文就破骨细胞在RA骨破坏中的研究进展作一综述。
作者 常俊 吴华香
机构地区 浙江大学医学院附属第二医院风湿免疫科
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2009年第5期346-349,共4页 Chinese Journal of Rheumatology
关键词 类风湿关节炎 破骨细胞 骨破坏 C-FOS基因 局部炎症 慢性滑膜炎 受体激活剂 关节软骨
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献15

  • 1Takayanagi H, lizuka H, Juji T, et al. Involvement of receptor activator of nuclear factor KB ligand/osteoclast differentiation factor on osteoelastogenesis from synoviocytes in rheumatoid arthritis. Arthritis Rheum, 2000, 43: 259-269.
  • 2曾润铭,张忠民,金大地.类风湿关节炎滑膜细胞向破骨细胞分化实验研究[J].中华风湿病学杂志,2005,9(3):149-153. 被引量：13
  • 3Grassi F, Cristino S, Toneguzzi S, et al. CXCL12 chemokine upregulates bone resorption and MMP-9 release by human osteoclasts: CXCL12 levels are increased in synovial and bone tissue of rheumatoid arthritis patients. J Cell Physiol, 2004, 199: 244- 251.
  • 4Weitzmann MN, Pacifici R. The role of T lymphocytes in bone metabolism. Immunol Rev, 2005, 208: 154-168.
  • 5Teitelbaum SL. Bone resorption by osteoclasts. Science, 2000, 289: 1504-1508.
  • 6Ju JH, Cho ML, Moon YM, et al. IL-23 induces receptor activator of NF-KB ligand expression on CD4^+ T cells and promotes osteoclastogenesis in an autoimmune arthritis model. J Immunol, 2008. 181: 1507-1518.
  • 7Kim HR, Cho ML, Kim KW, et al. Up-regulation of IL-23p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3-kinase, NF-KB and p38 MAPK-dependent signaling pathways. Rheumatology (Oxford), 2007, 46: 57-64.
  • 8Hoibauer LC, Heufelder AE. The role of osteoprotegerin and receptor activator of nuclear factor KB ligand in the pathogencsis and treatment of rheumatoid arthritis. Arthritis Rheum, 2001, 44: 253-259.
  • 9Lomaga MA, Yeh WC, Sarosi I, et al. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev, 1999, 13: 1015-1024.
  • 10Matsumoto M, Sudo T, Saito T, et al. Involvement of p38 mitogen activated protein kinase signaling pathway in osteodastogenesis mediated by receptor activator of NF-KB ligand (RANKL). J Biol Chem, 2000, 275: 155-161.

二级参考文献13

  • 1Cunnane G, FitzGerald O, Hummel KM, et al. Synovial tissue protease gene expression and joint erosions in early rheumatoid arthritis. Arthritis Rheum, 2001, 44: 1744-1753.
  • 2Smeets TJ, Barg EC, Kraan MC. Analysis of the cell infiltrate and expression of proinflammatory cytokines and matrix metalloproteinases in arthroscopic synovial biopsies: comparison with synovial samples from patients with end stage, destructive rheumatoid arthritis. Ann Rheum Dis, 2003, 62: 635-638.
  • 3Bresnihan B. Are synovial biopsies of diagnostic value. Arthritis Res Ther, 2003, 5: 271-278.
  • 4Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis . Arthritis Rheum, 1988, 31: 315-324.
  • 5Conaghan PG, O'Connor P, MeGonagle D, et al. Elucidation of the relationship between synovitis and bone damage: a randomized magnetic resonance imaging study of individual joints in patients with early rheumatoid arthritis. Arthritis Rheum, 2003, 48:64-71.
  • 6Lubberts E, Oppers-Walgreen B, Pettit AR, et al. Increase in expression of receptor activator of nuclear factor kappa B at sites of bone erosion correlates with progression of inflammation in evolving collagen-induced arthritis. Arthritis Rheum, 2002, 46: 3055-3064.
  • 7Romas E, Bakhatevski O, Hards DK, et al. Expression of osteoclast differentiation factor at sites of bone erosion in collagen-induced arthritis. Arthritis Rheum, 2000, 43: 821-826.
  • 8Danks L, Sabokba A, Gundle R, et al. Synovial macrophage-osteoclast differentiation in inflammatory arthritis. Ann Rheum Dis,2002, 61: 916-921.
  • 9Kong YY, Feige U, Sarosi I, et al. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature, 1999, 402: 304-309.
  • 10Suzuki Y, Tsutsumi Y, Nakagawa M, et al. Osteoclast-like cells in an in vitro model of bone destruction by rheumatoid synovium.Rheumatology (Oxford), 2001, 40: 673-682.

共引文献12

同被引文献8

引证文献1

二级引证文献3

中华风湿病学杂志
2009年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部