摘要
今年在墨西哥暴发的流感疫情来源于一种新的流感病毒:甲型H1N1病毒.这种病毒包括人源,禽源和猪源等甲型流感病毒基因片段,为混合毒株.比较了禽、猪和人的流感病毒在其天然宿主中的致病机理,主要目的是评估猪和禽的流感病毒成为人兽共患病的可能性,同时还评估猪在禽流感病毒传入人的过程中可能起到的作用.禽流感和猪流感作为人畜共患疾病,在流感病毒从动物到人的传播过程中起到关键的作用.猪作为流感病毒的中间宿主,具有混合器作用,人、猪、禽流感病毒可在其体内进行基因重排产生新病毒,并可能跨越种间屏障感染人类.但是流感病毒本身的跨越种间障碍传播不足以引起人流感的大暴发,动物流感病毒必须经过显著的遗传变异后才能使其在人群中长期存在.
This year an outbreak of influenza in Mexico comes from a new epidemic of influenza viruses： A/H1N1 influenza virus. This virus is a kind of virus mixture, including human, avian and swine influenza virus gene fragments. The pathogenic mechanism of avian, swine and human influenza virus in its natural host were compared. The main purpose is to assess the risk of which pigs and poultry has the possibility to become one of zoonotic disease and to assess the possible role in process of avian flu transmission from pigs to people. As zoonotic disease, avian influenza and swine influenza virus have the key role in the process of human infection. But the influenza virus spread of crossing species barrier is not sufficient to cause a large outbreak of human influenza. Animal influenza viruses must have a significant genetic variation before they could live for a long term in the crowd.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2009年第5期523-529,共7页
Progress In Biochemistry and Biophysics
基金
国家高技术研究发展计划(863)(2007AA100606)
中国科学院知识创新工程重要方向项目(KSCX2-YW-N-063)
中国科学院动物研究所前沿领域创新项目资助~~
关键词
禽流感
猪流感
基因重排
种间屏障
avian influenza, swine influenza, gene recombine, species barrier
