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肿瘤坏死因子α、转化生长因子β1在米非司酮抗早孕蜕膜中的表达

Expression of tumor necrosis factor alpha and transforming growth factor-beta 1 in decidua
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摘要 目的通过对早孕蜕膜组织中肿瘤坏死因子α(TNF-α)、转化生长因子β1(TGF-β1)表达的研究,探讨米非司酮应用于早孕药物流产的作用机制。方法用免疫组织化学方法(二步法)测定三组(药物流产组30例,人工流产+米索前列醇组20例,人工流产组20例)早孕蜕膜组织中TNF-α、TGF-β1的表达水平。结果用米非司酮的蜕膜组织中TNF-α含量显著升高、TGF-β1含量明显降低(P<0.05)。结论米非司酮可通过升高早孕蜕膜组织中TNF-α、降低TGF-β1的含量而达到抗早孕的目的。 Objective To study the anti-early pregnancy mechanism of Mifepristone by investigating the expression of tumor necrosis factor alpha （TNF-α） and transforming growth factor-beta 1 （TGF-β1） in decidua of early pregnancy. Methods Expression of TNF-α and TGF-β1 in decidua of early pregnancy were measured by using immunohistochemical assay （two-step） in 3 groups （drug abortion,n =30）, group 2 （induced abortion ＋ misoprostol,n =20） and group 3 （induced abortion,n =20）. Results The expression of TNF-α and TGF-β1 in group 1 were significantly higher than the other groups （P 〈 0. 05 ）. Conclusion Mifepristane can prevent pregnancy by increasing the TNF-α and TGF-β1 in decidua of early pregnancy.
作者 蒋晓莉 赵燕
机构地区 广西医科大学第一附属医院妇产科
出处 《广西医学》 CAS 2009年第4期466-468,共3页 Guangxi Medical Journal
基金 广西科学基金(桂科基236026)
关键词 药物流产 米非司酮 肿瘤坏死因子Α 转化生长因子Β1 蜕膜 Mffeprstone Tumor necrosis factor alpha Transforming growth factor-beta 1 Decidua
分类号 R714.1 [医药卫生—妇产科学] R392.1 [医药卫生—免疫学]
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参考文献10

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二级参考文献14

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共引文献13

广西医学
2009年 第4期

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