摘要
抑制素(Inhibin,INH)是转化生长因子β超家族成员之一。已经发现的抑制素有抑制素A和抑制素B两种分子形式。在女性,抑制素B主要由卵巢中、小窦状卵泡的颗粒细胞产生,特异性作用于腺垂体反馈性抑制卵泡刺激素(FSH)的分泌,同时抑制素B的分泌也受卵泡刺激素的调节。近年研究认为,抑制素B可能参与卵巢早衰(POF)的发病环节,并且是反映卵巢储备功能的重要指标,可用于卵巢早衰的早期诊断及预测,与卵巢早衰关系密切。
Inhibin （INH） is a member of the transforming growth factor β （TGF-β） super family. Inhibin A and inhibin B are the two known molecular forms of INH. Inhibin B, mainly produced by granular cells of middle and small antral follicles in female, can inhibit the secretion of follicle-stimulating hormone （FSH） through the specific effects on anterior pituitary. Meanwhile the secretion of inhibin B is regulated by FSH. Recent studies showed that inhibin B, as an important index of ovarian reserve, was involved in the etiology of premature ovarian failure （POF）. And inhibin B can be used in the early diagnosis and prediction of POF for its close relationship with POF.
出处
《国际生殖健康／计划生育杂志》
CAS
2009年第3期184-186,193,共4页
Journal of International Reproductive Health/Family Planning
关键词
抑制素B
卵泡刺激素
卵巢早衰
卵巢储备
Inhibin B
Follicle-stimulating hormone
Premature ovarian failure
Ovarian reserve
