摘要
目的通过检测川崎病(KD)患儿外周血中HMGB1含量变化,探讨其在川崎病(KD)中的病理生理机制及临床应用价值。方法选择山西省儿童医院心内科确诊为川崎病的住院患儿40例为研究对象,采用双抗体夹心ABC-ELISA法检测KD患儿急性期和恢复期外周血HMGB1含量;20例正常健康儿童作为对照。结果KD组患儿急性期血浆HMGB1含量高于恢复期和对照组,三组HMGB1含量变化有统计学意义(P<0.001);两两比较:KD急性期HMGB1高于恢复期及对照组,KD急性期CAL组HMGB1含量与NCAL组相比两者差异有统计学意义(P<0.001);KD恢复期CAL组HMGB1含量与NCAL组相比,两者差异有统计学意义(P<0.001)。相关性分析:KD组患儿急性期HMGB1含量与冠脉扩张呈正相关(r=0.828,P<0.01)。结论川崎病患儿急性期HMGB1含量高于恢复期与对照组。血浆HMGB1含量变化与KD的病变及冠状动脉损伤程度有一定的相关性。
Objective Through detecting plasma level of HMGB1 in acute and convalescent phase of Kawasaki Disease,the mechanism and clinical value of pathophysiology in Kawasaki Diseasewere explored. Methods Forty cases of Kawasaki Disease in heart medical department of shanxi province children＇s hospital were collected,plasma levels of HMGB1 by ABCELISA were detected. Twenty cases of normal children who went to the hospital for health examination were chosen as control group. Results Compared with normal control group and convalescent phase of kawasaki disease,HMGB1 level was increased in the acute phase of Kawasaki disease. There was statistical significance in three groups（P〈 0.001 ）. HMGB1 level in acute phase was higher than normal control group and convalescent group. Compared with non-coronary artery lesion group in acute phase, coronary artery lesion group had statistical significance in HMGB1 （P 〈 0.001 ）,There was statistical signifi- cance between coronary artery lesion and non-coronary artery lesion in convalescent phase. Correlation analysis showed that HMGB1 had positive relation with coronary artery dilatation in Kawasaki disease（r = 0.828,P〈 0.01 ）. Conclusion HMGB1 level was increased significantly in acute phase of Kawasaki Disease. The change of HMGBlin Kawasaki disease had a relationship with coronary artery lesion.
出处
《中国现代医生》
2009年第15期8-9,50,共3页
China Modern Doctor
